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Article
Open AccessBugSigDB captures patterns of differential abundance across a broad range of host-associated microbial signatures
The literature of human and other host-associated microbiome studies is expanding rapidly, but systematic comparisons among published results of host-associated microbiome signatures of differential abundance ...
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Article
Open AccessLife expectancy changes since COVID-19
The COVID-19 pandemic triggered an unprecedented rise in mortality that translated into life expectancy losses around the world, with only a few exceptions. We estimate life expectancy changes in 29 countries ...
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Article
Reporting guidelines for human microbiome research: the STORMS checklist
The particularly interdisciplinary nature of human microbiome research makes the organization and reporting of results spanning epidemiology, biology, bioinformatics, translational medicine and statistics a ch...
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Article
Open AccessPathogen burden and leukocyte telomere length in the United States
Prior studies in humans have suggested that telomere shortening may be accelerated by infection, but research on multiple pathogens and use of large population-based study samples has been limited. We estimate...
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Article
Open AccessEvaluation of Oral Cavity DNA Extraction Methods on Bacterial and Fungal Microbiota
The objective of this study was to evaluate the most effective method of DNA extraction of oral mouthwash samples for use in microbiome studies that utilize next generation sequencing (NGS). Eight enzymatic an...
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Article
Open AccessElevated HbA1c levels and the accumulation of differentiated T cells in CMV+ individuals
Biological ageing of the immune system, or immunosenescence, predicts poor health and increased mortality. A hallmark of immunosenescence is the accumulation of differentiated cytotoxic T cells (CD27−CD45RA+/−; o...
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Article
Open AccessCytomegalovirus antibodies in dried blood spots: a minimally invasive method for assessing stress, immune function, and aging
Cytomegalovirus (CMV) is a prevalent herpesvirus with links to both stress and aging. This paper describes and validates a minimally invasive method for assessing antibodies against CMV in finger stick whole b...
