-
Article
Open AccessPrevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition
Microbiota-directed complementary food (MDCF) formulations have been designed to repair the gut communities of malnourished children. A randomized controlled trial demonstrated that one formulation, MDCF-2, im...
-
Article
Open AccessBioactive glycans in a microbiome-directed food for children with malnutrition
Evidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition1–4. Here we analyse biospecimens from a randomized, controlled trial of a microbiome-direc...
-
Article
Open AccessDevelo** shelf-stable Microbiota Directed Complementary Food (MDCF) prototypes for malnourished children: study protocol for a randomized, single-blinded, clinical study
Childhood undernutrition is a major public health concern that needs special attention to achieve 2025 global nutrition targets. Moderate acute malnutrition (MAM), manifest as wasting (low weight-for-height), ...
-
Article
Open AccessProof-of-concept study of the efficacy of a microbiota-directed complementary food formulation (MDCF) for treating moderate acute malnutrition
Childhood undernutrition remains a significant global health challenge accounting for over half of all under 5 child mortality. Moderate acute malnutrition (MAM), which leads to wasting [weight-for-length z-sc...
-
Article
Open AccessApplying indirect open-circuit calorimetry to study energy expenditure in gnotobiotic mice harboring different human gut microbial communities
Given the increasing use of gnotobiotic mouse models for deciphering the effects of human microbial communities on host biology, there is a need to develop new methods for characterizing these animals while ma...
-
Article
Open AccessStudy of Environmental Enteropathy and Malnutrition (SEEM) in Pakistan: protocols for biopsy based biomarker discovery and validation
Environmental Enteropathy (EE), characterized by alterations in intestinal structure, function, and immune activation, is believed to be an important contributor to childhood undernutrition and its associated ...
-
Article
Author Correction: Transposable elements drive widespread expression of oncogenes in human cancers
In the version of this article initially published, grant PF-17-201-01-TBG from the American Cancer Society to author Erica C. Pehrsson was not included in the Acknowledgements. The error has been corrected in...
-
Article
Open AccessMoving pictures of the human microbiome
Understanding the normal temporal variation in the human microbiome is critical to develo** treatments for putative microbiome-related afflictions such as obesity, Crohn's disease, inflammatory bowel disease...
-
Article
Direct sequencing of the human microbiome readily reveals community differences
Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to stu...
-
Article
The Human Microbiome Project
A strategy to understand the microbial components of the human genetic and metabolic landscape and how they contribute to normal physiology and predisposition to disease.
