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Article
Open AccessCirculating exosomal mRNA profiling identifies novel signatures for the detection of prostate cancer
The landscape and characteristics of circulating exosomal messenger RNAs (emRNAs) are poorly understood, which hampered the accurate detection of circulating emRNAs. Through comparing RNA sequencing data of ci...
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Article
Open AccessKDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer
Lysine (K)-specific demethylase 6B (KDM6B), a stress-inducible H3K27me3 demethylase, plays oncogenic or antitumoral roles in malignant tumors depending on the type of tumor cell. However, how this histone modi...
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Article
Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate
Monoamine oxidase A (MAOA) is a mitochondrial enzyme, which degrades monoamine neurotransmitters and dietary amines and produces H2O2. Recent studies have shown increased MAOA expression in prostate cancer (PCa),...
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The PI3K-mTOR Pathway in Prostate Cancer: Biological Significance and Therapeutic Opportunities
Despite the recent development of new and improved surveillance and treatment strategies, lethal prostate cancer (PCa) phenotypes with castration resistance (CRPC) and metastatic lesions remain poorly understo...
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Article
Transcriptional regulation and multiple functions of MAO genes
Monoamine oxidase (MAO) A and MAO B are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide. These two isoenzymes hav...
