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The EDS1–PAD4–ADR1 node mediates Arabidopsis pattern-triggered immunity

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  1. Article

    Open Access

    Substrate-induced condensation activates plant TIR domain proteins

    Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain mediate recognition of strain-specific pathogen effectors, typically via their C-...

    Wen Song, Li Liu, Dongli Yu, Hanna Bernardy, Jan Jirschitzka, Shijia Huang in Nature (2024)

  2. Article

    Open Access

    The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants

    Iron is critical for host–pathogen interactions. While pathogens seek to scavenge iron to spread, the host aims at decreasing iron availability to reduce pathogen virulence. Thus, iron sensing and homeostasis ...

    Matthieu Pierre Platre, Santosh B. Satbhai, Lukas Brent in Nature Communications (2022)

  3. Article

    Open Access

    Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity

    Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 “helper” NLRs (RNLs) cooperate wi...

    **nhua Sun, Dmitry Lapin, Joanna M. Feehan, Sara C. Stolze in Nature Communications (2021)

  4. Article

    Open Access

    An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis

    Plant intracellular NLR receptors recognise pathogen interference to trigger immunity but how NLRs signal is not known. Enhanced disease susceptibility1 (EDS1) heterodimers are recruited by Toll-interleukin1-r...

    Deepak D. Bhandari, Dmitry Lapin, Barbara Kracher in Nature Communications (2019)