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3 Result(s)

within James T. Rutka Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. No Access

    Article

    Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

    Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.

    Stephen C. Mack, Kristian W. Pajtler, Lukas Chavez, Konstantin Okonechnikov… in Nature (2018)

  2. No Access

    Article

    Divergent clonal selection dominates medulloblastoma at recurrence

    The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon–driven, functional ...

    A. Sorana Morrissy, Livia Garzia, David J. H. Shih, Scott Zuyderduyn, ** Huang… in Nature (2016)

  3. Article

    Open Access

    Subgroup-specific structural variation across 1,000 medulloblastoma genomes

    Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medullobl...

    Paul A. Northcott, David J. H. Shih, John Peacock, Livia Garzia… in Nature (2012)

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