8 Result(s)

Article

Designing a preliminary adaptive study to inform a biomarker trial in Psoriasis

Andrew T Prevost, Jack Bowden in Trials (2011)

Article

Impact of lack-of-benefit stop** rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome

In 2011, Royston et al. described technical details of a two-arm, multi-stage (TAMS) design. The design enables a trial to be stopped part-way through recruitment if the accumulating data suggests a lack of benef...

Babak Choodari-Oskooei, Mahesh KB Parmar, Patrick Royston, Jack Bowden in Trials (2013)

Article

Revisiting the multi-armed bandit model for the optimal design of clinical trials: benefits and drawbacks

Sofia S Villar, Jack Bowden, James Wason in Trials (2013)

Article

Impact of lack-of-benefit stop** rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome

Babak Choodari-Oskooei, Max KB Parmar, Patrick Royston, Jack Bowden in Trials (2013)

Article

Adaptive enrichment in biomarker-stratified clinical trial design

Deepak Parashar, Jack Bowden, Colin Starr, Lorenz Wernisch, Adrian Mander in Trials (2013)

Article

Correcting for selection bias in two-stage trials with multiple correlated outcomes: application to seamless phase ii/iii clinical trials

David Robertson, A Toby Prevost, Jack Bowden in Trials (2015)

Article

Patient drift and response-adaptive randomisation: impact and solutions

Sofia S Villar, James Wason, Jack Bowden in Trials (2015)

Article

Type I error control in biomarker-stratified clinical trials

Deepak Parashar, Jack Bowden, Colin Starr, Lorenz Wernisch, Adrian Mander in Trials (2015)