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  1. No Access

    Article

    Chronic infusion of clonidine does not alleviate spontaneous morphine withdrawal symptoms in rats

    Opiate withdrawal is associated with behavioural symptoms and a sympathetic hyperactivity, the latter being sensitive to clonidine. The central question is whether behavioural symptoms would be also sensitive ...

    J. W. van der Laan, C. Jansen van't Land in Psychopharmacology (1992)

  2. Article

    Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: Suppression by a 2-adrenoceptor stimulation

    J. W. van der Laan, G. Weick, F. C. Hillen in Psychopharmacology (1984)

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    Article

    Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: Suppression by α2-Adrenoceptor stimulation

    The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50

    J. W. van der Laan, G. Weick, F. C. Hillen in Psychopharmacology (1983)

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    Article

    A dual role for GABA in quasi-morphine abstinence behavior induced by di-n-propylacetate involving both initiation and termination

    Di-n-propylacetate (DPA) induces a behavioral syndrome in rats resembling morphine abstinence behavior. The inhibitory action of DPA on GABA degradation, resulting in an enhanced release of GABA, is probably r...

    J. W. Van der Laan, J. Bruinvels in Psychopharmacology (1981)