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Article
Chronic infusion of clonidine does not alleviate spontaneous morphine withdrawal symptoms in rats
Opiate withdrawal is associated with behavioural symptoms and a sympathetic hyperactivity, the latter being sensitive to clonidine. The central question is whether behavioural symptoms would be also sensitive ...
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Article
Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: Suppression by a 2-adrenoceptor stimulation
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Article
Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: Suppression by α2-Adrenoceptor stimulation
The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50
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Article
A dual role for GABA in quasi-morphine abstinence behavior induced by di-n-propylacetate involving both initiation and termination
Di-n-propylacetate (DPA) induces a behavioral syndrome in rats resembling morphine abstinence behavior. The inhibitory action of DPA on GABA degradation, resulting in an enhanced release of GABA, is probably r...