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  1. No Access

    Article

    Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in naive and cyclosporin-treated low-responder murine strains

    We have previously shown that essential fatty acid (EFA) deficiency prevents diabetes and ameliorates insulitis in low-dose streptozotocin (LDS)-treated male CD-1 mice. The effects of EFA deficiency on the inc...

    J. R. Wright Jr., R. B. Fraser, S. Kapoor, H. W. Cook in Acta Diabetologica (1995)

  2. Article

    The anti-diabetogenic effect of essential fatty acid deficiency in multiple low-dose streptozotocin-treated mice persists if essential fatty acid repletion occurs outside of a brief window of susceptibility

    We have previously shown that essential fatty acid deficiency prevents diabetes mellitus and ameliorates insulitis in multiple low-dose streptozotocin-treated male CD-1 mice and that repletion with 99% pure me...

    J. R. Wright Jr., B. Haliburton, H. Russell, M. Henry, R. Fraser… in Diabetologia (1991)

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    Effect of niacin/nicotinamide deficiency on the diabetogenic effect of streptozotocin

    Weanling CD-1 mice were fed either a control diet or a diet deficient in niacin/nicotinamide for one month and then injected i.v. with 60, 80, 100, 120, 140, or 160 mg/kg streptozotocin. Mice on the deficient ...

    J. R. Wright Jr, J. Mendola, P. E. Lacy in Experientia (1988)