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  1. No Access

    Article

    The potential for efficacy of the modified (ICP 34.5−) herpes simplex virus HSV1716 following intratumoural injection into human malignant glioma: a proof of principle study

    We have previously demonstrated the safety of intratumoural administration of the selectively replication-competent herpes simplex virus mutant HSV1716 in patients with high-grade glioma (HGG). Here we show it...

    V Papanastassiou, R Rampling, M Fraser, R Petty, D Hadley, J Nicoll… in Gene Therapy (2002)

  2. No Access

    Article

    Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma

    The herpes simplex virus (HSV) ICP34.5 null mutant 1716 replicates selectively in actively dividing cells and has been proposed as a potential treatment for cancer, particularly brain tumours. We present a cli...

    R Rampling, G Cruickshank, V Papanastassiou, J Nicoll, D Hadley, D Brennan… in Gene Therapy (2000)