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Article
Acquired factor VIII inhibitor preceding chronic lymphocytic leukemia
An acquired factor VIII inhibitor was found in an 82-year-old woman who presented with numerous spontaneously appearing ecchymoses. Coagulation studies revealed the presence of a prolonged activated partial th...
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Article
Severe bleeding in a patient with spontaneous factor VIII inhibitor and acute exacerbation of chronic pancreatitis
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Article
Physical training decreases plasma thrombomodulin in Type I and Type II diabetic patients
Aims/hypothesis. Endothelial damage is an early step in the pathogenesis of atherosclerosis and its improvement through physical training can contribute to the known reduction of cardiovascular r...
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Article
Coronary artery disease diagnosis based on exercise electrocardiogram indexes from repolarisation, depolarisation and heart rate variability
Several indexes have been reported to improve the accuracy of exercise test electrocardiogram (ECG) analysis in the diagnosis of coronary artery disease (CAD), compared with the classical ST depression criteri...
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Article
Gamow Vectors in Exactly Solvable Models
Through two examples: the Friedrichs model and a particular case of central potential scattering, we illustrate the way of constructing Gamow vectors.
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Chapter
Hémofiltration et plasmaphérèse
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Article
Pseudo-Hermitian Hamiltonians: tale of two potentials
For the non-Hermitian, PT-symmetric potentials V = m 2 x 2 + gx 2(ix)ν with ν = 1 and 2, we construct the Q operator which gives both the positive-definite metric and an equivalent Hermitian Hamiltonian h. For th...
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Chapter and Conference Paper
Neural Networks Based Approach to remove Baseline drift in Biomedical Signals
Nowadays there exist different approaches to cancel out noise effect and baseline drift in biomedical signals. However, none of them can be considered as completely satisfactory. In this work an artificial neu...
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Chapter and Conference Paper
Sample Entropy Analysis of Electrocardiograms to Characterize Recurrent Atrial Fibrillation
In a substantial number of patients atrial fibrillation (AF) recurs after successful electrical cardioversion, but at present there are no reliable clinical markers for confidently identifying the patients in ...
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Article
Cervical necrotizing fasciitis: 8-years’ experience of microbiology
Cervical necrotizing fasciitis (CNF) is a life-threatening complication of pharyngeal or dental infections. The aim of this paper was to investigate whether dental or pharyngeal source result from different pa...
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Article
Silibinin inhibits hypoxia-inducible factor-1α and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy
The hypoxia-inducible factor 1 (HIF-1) plays a critical role for tumour adaptation to microenvironmental hypoxia, and represents an appealing chemotherapeutic target. Silibinin is a nontoxic flavonoid reported...
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Chapter
Hémofiltration et plasmaphérèse
L’hémofiltration continue et les techniques dérivées, regroupées sous le terme d’épuration extra-rénale continue, sont de plus en plus largement utilisées chez les patients de réanimation. L’hémofiltration con...
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Article
Gradients de PCO2 : un reflet fiable de la perfusion macroet microcirculatoire
L’augmentation des gradients veinoartériel et tissuartériel en CO2 (Pv-aCO2 et Pt-aCO2) est un phénomène régulièrement retrouvé dans des travaux expérimentaux ou des études cliniques sur les défaillances circulat...
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Article
Robust Volterra Filter Design for Enhancement of Electroencephalogram Signal Processing
Electroencephalogram (EEG) recordings often experience interference by different kinds of noise, including white, muscle, and baseline, severely limiting its utility. The recent research has demonstrated that ...
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Article
Dynamic Fuzzy Neural Network Based Learning Algorithms for Ocular Artefact Reduction in EEG Recordings
Frequent occurrence of ocular artefacts leads to serious problems in reading and analysing the electroencephalogram (EEG) signal. These artefacts have high amplitude and overlap** frequency band with the phy...
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Article
Open AccessValidation and utilisation of high-coverage next-generation sequencing to deliver the pharmacological audit trail
Predictive biomarker development is a key challenge for novel cancer therapeutics. We explored the feasibility of next-generation sequencing (NGS) to validate exploratory genomic biomarkers that impact phase I...
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Article
Open AccessA first-in-human study of the anti-α5β1 integrin monoclonal antibody PF-04605412 administered intravenously to patients with advanced solid tumors
A first-in-human clinical trial of a fully human, Fc-engineered IgG1 monoclonal antibody targeting integrin α5β1 was conducted to evaluate tolerability, maximum tolerated dose, pharmacokinetics, pharmacodynami...
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Article
Open AccessTumour responses following a steroid switch from prednisone to dexamethasone in castration-resistant prostate cancer patients progressing on abiraterone
Abiraterone is a CYP17A1 inhibitor that improves survival in castration-resistant prostate cancer (CRPC). Abiraterone is licensed in combination with prednisone 5 mg twice daily to prevent a syndrome of second...
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Article
Open AccessEconomic Analysis of Thrombo inCode, a Clinical–Genetic Function for Assessing the Risk of Venous Thromboembolism
Patients with venous thromboembolism (VTE) commonly have an underlying genetic predisposition. However, genetic tests nowadays in use have very low sensitivity for identifying subjects at risk of VTE. Thrombo ...
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Article
Cancellation of Powerline Interference from Biomedical Signals Using an Improved Affine Projection Algorithm
Powerline contamination of recorded signals represents a major source of noise in electrophysiology and impairs the use of recordings for research. Furthermore it degrades the signal quality and overwhelms tin...