Skip to main content

8 Result(s)

within J. M. Littleton Remove this filter

and

  1. No Access

    Article

    Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze

    Rationale: Drugs that reduce relapse in alcoholics are thought to inhibit either positive reinforcement for drinking (e.g. naltrexone) or negative reinforcement (e.g. acamprosate), and m...

    J. C. Cole, J. M. Littleton, H. J. Little in Psychopharmacology (2000)

  2. No Access

    Article

    Effects of repeated ethanol administration in the plus maze; a simple model for conditioned abstinence behaviour

    Classical conditioning is considered to be an important factor in drug dependence. Exposure to an environment in which alcohol has been repeatedly consumed may produce feelings of anxiety and dysphoria in a c...

    J. C. Cole, J. M. Littleton, H. J. Little in Psychopharmacology (1999)

  3. No Access

    Chapter and Conference Paper

    Agents Which Modify Channels as Potential Treatments in Alcohol Withdrawal

    The genesis of alcohol physical dependence is usually viewed as a consequence of adaptive mechanisms within the central nervous system. In this scheme alcohol produces inhibitory effects on neurones by some me...

    J. M. Littleton, O. Bouchenafa in Novel Pharmacological Interventions for Alcoholism (1992)

  4. No Access

    Chapter

    The Role of Calcium Channels in Ethanol Dependence

    Calcium channels in neurones are divided into those activated by neurotransmitter-receptor interactions, and voltage-operated channels. The conductance of the latter increases as the membrane potential decreas...

    H. J. Little, J. M. Littleton in Alcoholism (1991)

  5. No Access

    Article

    Effects of dihydropyridine calcium channel antagonists in ethanol withdrawal; doses required, stereospecificity and actions of Bay K 8644

    The effects of dihydropyridine calcium channel antagonists, and the calcium channel activator, Bay K 8644, were examined on the convulsive behaviour induced by handling in mice following withdrawal from chroni...

    J. M. Littleton, H. J. Little, M. A. Whittington in Psychopharmacology (1990)

  6. No Access

    Chapter

    The Effect of Alcohol on Human Platelet Function. The Role of Platelet Membrane and Plasma Lipids

    There have been several large epidemiological surveys in the last 5 years (Yano et al., 1977; Kozarevic et al., 1980) which have provided evedence that a moderate intake of ethanol is protective against cardio...

    C. G. Fenn, J. M. Littleton in Clinical Implications of Recent Research R… (1983)

  7. No Access

    Chapter

    Ethanol-Induced Alteration in Membrane Phospholipid Composition: Possible Relationship to Development of Cellular Tolerance to Ethanol

    There is now considerable evidence that unicellular organisms adapt to environmental or pharmacological agents which alter membrane fluidity by incorporating different fatty acids into the phospholipids of the...

    J. M. Littleton, S. J. Grieve, P. J. Griffiths, G. R. John in Biological Effects of Alcohol (1980)

  8. No Access

    Chapter

    Alcoholism and schizophrenia: A basic science approach

    In this chapter I do not intend to draw any inferences as to a connection between alcoholism and schizophrenia. I feel that would not be justified by the evidence available. I do intend to draw some parallels ...

    J. M. Littleton in Biochemistry of Schizophrenia and Addiction (1980)