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Article
Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze
Rationale: Drugs that reduce relapse in alcoholics are thought to inhibit either positive reinforcement for drinking (e.g. naltrexone) or negative reinforcement (e.g. acamprosate), and m...
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Article
Effects of repeated ethanol administration in the plus maze; a simple model for conditioned abstinence behaviour
Classical conditioning is considered to be an important factor in drug dependence. Exposure to an environment in which alcohol has been repeatedly consumed may produce feelings of anxiety and dysphoria in a c...
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Chapter and Conference Paper
Agents Which Modify Channels as Potential Treatments in Alcohol Withdrawal
The genesis of alcohol physical dependence is usually viewed as a consequence of adaptive mechanisms within the central nervous system. In this scheme alcohol produces inhibitory effects on neurones by some me...
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Chapter
The Role of Calcium Channels in Ethanol Dependence
Calcium channels in neurones are divided into those activated by neurotransmitter-receptor interactions, and voltage-operated channels. The conductance of the latter increases as the membrane potential decreas...
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Article
Effects of dihydropyridine calcium channel antagonists in ethanol withdrawal; doses required, stereospecificity and actions of Bay K 8644
The effects of dihydropyridine calcium channel antagonists, and the calcium channel activator, Bay K 8644, were examined on the convulsive behaviour induced by handling in mice following withdrawal from chroni...
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Chapter
The Effect of Alcohol on Human Platelet Function. The Role of Platelet Membrane and Plasma Lipids
There have been several large epidemiological surveys in the last 5 years (Yano et al., 1977; Kozarevic et al., 1980) which have provided evedence that a moderate intake of ethanol is protective against cardio...
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Chapter
Ethanol-Induced Alteration in Membrane Phospholipid Composition: Possible Relationship to Development of Cellular Tolerance to Ethanol
There is now considerable evidence that unicellular organisms adapt to environmental or pharmacological agents which alter membrane fluidity by incorporating different fatty acids into the phospholipids of the...
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Chapter
Alcoholism and schizophrenia: A basic science approach
In this chapter I do not intend to draw any inferences as to a connection between alcoholism and schizophrenia. I feel that would not be justified by the evidence available. I do intend to draw some parallels ...