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Article
The French Model of Senior Housing to Tackle Housing Inequalities
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Article
Ten Years after the National Alzheimer’s Plan: Dementia Remains a Hidden Syndrome in France
Ten years after the implementation of the French Plan on Alzheimer’s Disease (2008–2012), the present study aimed at describing the situation of the persons living with dementia in terms of diagnosis and high-...
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Article
Social Vulnerability Predicts Frailty: Towards a Distinction between Fragility and Frailty?
All definitions of frailty converge in two aspects: the notion of loss or decline and the ability to predict negative health outcomes. Numerous factors were reported to be associated with frailty among which b...
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Article
Co-Occurrence of Geriatric Syndromes and Diseases in the General Population: Assessment of the Dimensions of Aging
The co-occurrence of multiple medical or psychosocial conditions (geriatric syndromes (GS) and age-related diseases) is a growing concern in older people. Given the diversity of these conditions and their comp...
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Article
Effects of Age, Level of Education and HIV Status on Cognitive Performance in West African Older Adults: The West Africa IeDEA Cohort Collaboration
An in-depth understanding of the impact of aging, cognitive reserve, and HIV status on cognitive function is needed in older West African adults. Ninety-nine HIV-negative and 334 HIV-positive adults aged ≥ 50 ...
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Article
A Literature Review of Healthy Aging Trajectories Through Quantitative and Qualitative Studies: A Psycho-Epidemiological Approach on Community-Dwelling Older Adults
The population of older adults over 60 years is growing faster than any other age group and will more than double between 2020 and 2050. This increase has led to clinical, public health, and policy interest in...
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Article
Older People Facing the Crisis of COVID-19: Between Fragility and Resilience
The health crisis we are facing is challenging seniors’ resources and capacities for adaptation and resilience. The PACOVID survey, set up a few days after containment, investigates their psychological and soc...
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Article
Frailty Index, Hospital Admission and Number of Days Spent in Hospital in Nursing Home Residents: Results from the INCUR Study
To investigate the predictive capacity of an age-related deficit accumulation index (the so-called Frailty Index [FI] proposed by Rockwood) for hospital admission (HA) and number of days spent in hospital (DSH...
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Article
Psychosocioeconomic Precariousness and Frailty: The Respective Contribution in Predicting Mortality
Low socioeconomic status and frailty are factors of vulnerability in old age. They are both well-known risk factors of death. On the other hand, low socioeconomic status has been reported as a predictor of fra...
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Article
Effect of Multidomain Intervention, Omega-3 Polyunsaturated Fatty Acids Supplementation or their Combinaison on Cognitive Function in Non-Demented Older Adults According to Frail Status: Results from the MAPT Study
The aim of this study was to explore whether multidomain intervention (MI) and Omega-3 Polyunsaturated Fatty Acids supplementation can modify the cognitive function on elderly according to frail status.
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Article
17q21.31 duplication causes prominent tau-related dementia with increased MAPT expression
To assess the role of rare copy number variations in Alzheimer's disease (AD), we conducted a case–control study using whole-exome sequencing data from 522 early-onset cases and 584 controls. The most recurren...
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Article
SORL1 rare variants: a major risk factor for familial early-onset Alzheimer’s disease
The SORL1 protein plays a protective role against the secretion of the amyloid β peptide, a key event in the pathogeny of Alzheimer’s disease. We assessed the impact of SORL1 rare variants in early-onset Alzheime...
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Article
Why is later age at retirement beneficial for cognition? Results from a French population-based study
To determine whether and how age at retirement influences the risk of dementia. The association between the age at retirement, the number of working years and the risk of dementia was evaluated over 12 years o...
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Article
A novel Alzheimer disease locus located near the gene encoding tau protein
APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’...
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Article
Analysing time to event data in dementia prevention trials: The example of the guidage study of EGB761®
Time-to-event analysis is frequently used in medical research to investigate potential diseasemodifying treatments in neurodegenerative diseases. Potential treatment effects are generally evaluated using the l...
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Article
Diet, alcohol consumption and cognitive disorders in Central Africa: A study from the EPIDEMCA program
Western research into dementia has focused on finding effective means of prevention, particularly through nutrition. To date, however, little is known about the relationship between diet and cognitive disorder...
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Article
A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly
Amyloid beta (Aβ) peptides are the major components of senile plaques, one of the main pathological hallmarks of Alzheimer disease (AD). However, Aβ peptides' functions are not fully understood and seem to be ...
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Article
Change in leisure and social activities and risk of dementia in elderly cohort
To investigate the association of the change in practice of leisure and social activities with dementia risk taking into account the evolution of cognitive performances.
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Article
Hierarchical structure of the activities of daily living scale in dementia
To describe the sequence of basic activities of daily living (ADL) loss to determine whether there is a hierarchical structure of ADL in dementia in two epidemiological prospective studies: the Paquid study an...
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Article
Erratum to: Dyspnea: A Strong Independent Factor for Long-Term Mortality in the Elderly
