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Topology Optimization in Linear Elasticity, Plasticity and Fracture Mechanics

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  1. Article

    Open Access

    Long-term efficacy of imatinib mesylate in patients with advanced Tenosynovial Giant Cell Tumor

    Tenosynovial giant cell tumors (TGCT), are rare colony stimulating factor-1(CSF-1)-driven proliferative disorders affecting joints. Diffuse-type TGCT often causes significant morbidity due to local recurrences...

    F. G. M. Verspoor, M. J. L. Mastboom, G. Hannink, R. G. Maki in Scientific Reports (2019)

  2. Article

    Open Access

    A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma

    Preoperative radiotherapy (RT) is commonly used to treat localised soft-tissue sarcomas (STS). Hypoxia is an important determinant of radioresistance. Whether antiangiogenic therapy can ‘normalise’ tumour vasc...

    J Lewin, K K Khamly, R J Young, C Mitchell, R J Hicks in British Journal of Cancer (2014)

  3. Article

    Open Access

    Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis

    Biallelic protein-truncating mutations in the adenomatous polyposis coli (APC) gene are prevalent in sporadic colorectal cancer (CRC). Mutations may not be fully inactivating, instead producing WNT/β-catenin sign...

    M Christie, R N Jorissen, D Mouradov, A Sakthianandeswaren, S Li, F Day, C Tsui in Oncogene (2013)