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  1. Article

    Open Access

    Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis

    Biallelic protein-truncating mutations in the adenomatous polyposis coli (APC) gene are prevalent in sporadic colorectal cancer (CRC). Mutations may not be fully inactivating, instead producing WNT/β-catenin sign...

    M Christie, R N Jorissen, D Mouradov, A Sakthianandeswaren, S Li, F Day, C Tsui… in Oncogene (2013)

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