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Article
Erratum: FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction
Correction to: Oncogene (2015) 34, 2505−2515; doi:10.1038/onc.2014.184; published online 7 July 2014 Since the publication of the above article, the authors have noticed that the PUMA immunostainings in the ‘A...
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Article
Open AccessIntegrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma
Long non-coding RNAs (lncRNAs) have a critical role in cancer initiation and progression, and thus may mediate oncogenic or tumor suppressing effects, as well as be a new class of cancer therapeutic targets. W...
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Article
Erratum: FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction
Correction to: Oncogene (2015) 34, 2505–2515; doi:10.1038/onc.2014.184; published online 7 July 2014 Since the publication of the above paper, the authors found a misplacing band in Figure 2e. The correct vers...
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Article
Erratum: FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction
Correction to: Oncogene (2015) 34, 2505–2515; doi:10.1038/onc.2014.184; published online 7 July 2014 Since the online publication of the above article, it has been noted that affiliation for M-C Lee was incorr...
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Article
FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction
Fragile histidine triad (FHIT) loss by the two-hit mechanism of loss of heterozygosity and promoter hypermethylation commonly occurrs in non-small cell lung cancer (NSCLC) and may confer cisplatin resistance i...
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Article
The MZF1/c-MYC axis mediates lung adenocarcinoma progression caused by wild-type lkb1 loss
Liver kinase B1 (LKB1) loss in lung adenocarcinoma is commonly caused by genetic mutations, but these mutations rarely occur in Asian patients. We recently reported wild-type LKB1 loss via the alteration of NK...
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Article
Phosphorylation of paxillin confers cisplatin resistance in non-small cell lung cancer via activating ERK-mediated Bcl-2 expression
Paxillin (PXN) is required for receptor tyrosine kinase-mediated ERK activation, and the activation of the Raf/MEK/ERK cascade has been linked with Bcl-2 expression. We hypothesized that phosphorylation of PXN...
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Article
Inflammatory markers in cord blood or maternal serum for early detection of neonatal sepsis—a systemic review and meta-analysis
To perform a quantitative review of the evidence on the diagnostic value of inflammatory markers in maternal serum or umbilical cord blood for the diagnosis of early-onset neonatal sepsis (EONS).
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Article
Gene polymorphisms of adiponectin and leptin receptor are associated with early onset of type 2 diabetes mellitus in the Taiwanese population
Adipocytokine genes encoding adiponectin (ADIPOQ) and the leptin receptor (LEPR) affect glucose and fatty acid metabolism. The purpose of this study was to examine the association between early-onset type 2 diabe...
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Article
Genome-wide association study of bipolar I disorder in the Han Chinese population
We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four reg...
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Article
The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer
The neuronal repellent SLIT2 is repressed in a number of cancer types primarily through promoter hypermethylation. SLIT2, however, has not been studied in prostate cancer. Through genome-wide location analysis...
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Article
More evidence supports the association of PPP3CC with schizophrenia
Calcineurin is a calcium/calmodulin-dependent protein phosphatase composed of two subunits, a regulatory subunit of calcineurin B (CNB) and a catalytic subunit of calcineurin A (CNA). PPP3CC is the γ isoform of C...
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Article
Indiscernible benefit of high-resolution HLA ty** in improving long-term clinical outcome of unrelated umbilical cord blood transplant
The success of allogeneic hematopoietic stem cell transplantation depends in part on the accuracy of human leukocyte antigen (HLA) matching between the donor–recipient pair. The higher the number of matching H...