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    Article

    WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function

    The Hedgehog-GLI (HH-GLI) signaling plays a critical role in controlling growth and tissue patterning during embryogenesis and is implicated in a variety of human malignancies, including those of the skin. Pho...

    S Pandolfi, V Montagnani, J Y Penachioni, M C Vinci, B Olivito, L Borgognoni in Oncogene (2013)

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    Open Access

    SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells

    Melanoma is one of the most aggressive types of human cancer, characterized by enhanced heterogeneity and resistance to conventional therapy at advanced stages. We and others have previously shown that HEDGEHO...

    R Santini, S Pietrobono, S Pandolfi, V Montagnani, M D'Amico, J Y Penachioni in Oncogene (2014)