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  1. No Access

    Article

    AML1/ETO cooperates with HIF1α to promote leukemogenesis through DNMT3a transactivation

    The mechanisms by which AML1/ETO (A/E) fusion protein induces leukemogenesis in acute myeloid leukemia (AML) without mutagenic events remain elusive. Here we show that interactions between A/E and hypoxia-indu...

    X N Gao, F Yan, J Lin, L Gao, X L Lu, S C Wei, N Shen, J X Pang, Q Y Ning… in Leukemia (2015)

  2. No Access

    Article

    Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells

    Obesity is becoming more prevalent worldwide and is a major risk factor for cancer development. Acute myeloid leukemia (AML), the most common acute leukemia in adults, remains a frequently fatal disease. Here ...

    F Yan, N Shen, J X Pang, Y W Zhang, E Y Rao, A M Bode, A Al-Kali, D E Zhang… in Leukemia (2017)

  3. No Access

    Article

    A vicious loop of fatty acid-binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target

    Aberrant DNA methylation mediated by deregulation of DNA methyltransferases (DNMT) is a key hallmark of acute myeloid leukemia (AML), yet efforts to target DNMT deregulation for drug development have lagged. W...

    F Yan, N Shen, J X Pang, N Zhao, Y W Zhang, A M Bode, A Al-Kali, M R Litzow… in Leukemia (2018)