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Article
Open AccessPassive and active roles of fat-free mass in the control of energy intake and body composition regulation
While putative feedback signals arising from adipose tissue are commonly assumed to provide the molecular links between the body’s long-term energy requirements and energy intake, the available evidence sugges...
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Article
Body composition phenotypes in pathways to obesity and the metabolic syndrome
Dynamic changes in body weight have long been recognized as important indicators of risk for debilitating diseases. While weight loss or impaired growth can lead to muscle wastage, as well as to susceptibility...
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Article
The thrifty ‘catch-up fat’ phenotype: its impact on insulin sensitivity during growth trajectories to obesity and metabolic syndrome
The analyses of large epidemiological databases have suggested that infants and children who show catch-up growth, or adiposity rebound at a younger age, are predisposed to the development of obesity, type 2 d...
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Article
Pathways from weight fluctuations to metabolic diseases: focus on maladaptive thermogenesis during catch-up fat
It has long been known that obesity is a high risk factor for cardiovascular diseases. In more recent years, the analysis of several large epidemiological databases has also revealed that, independently of exc...
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Article
An adipose-specific control of thermogenesis in body weight regulation
Much of our understanding about ‘adaptive thermogenesis’ as a control system in mammalian weight regulation derives from studies of experimental starvation and overfeeding, and these have served to characteriz...
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Article
Low-protein overfeeding: a tool to unmask susceptibility to obesity in humans
In search for an approach to identify physiological targets for therapeutic intervention in obesity management, we have revisited the classic human overfeeding studies of the 1960s, with new emphasis on a ‘sub...