13 Result(s)

Article

Immune-complex disease in mice and humans given C. parvum

The present studies in mice and cancer-bearing patients, treated with C. parvum (CP) immunotherapy, were to determine the effects of CP on the production of immune complexes (IC) and associated disease. Using the...

H D Mitcheson, J Uff, B A Pussell, M Brill, J E Castro in British Journal of Cancer (1980)

Article

Single versus multiple human-equivalent doses of C. parvum in mice: neutralization of the anti-metastatic effect

The murine dose of i.v. C. parvum (466 microgram) was compared with a single, low, human-equivalent dose of 70 microgram and with repeated weekly low doses. All treatments increased the antibody titre against C. ...

H D Mitcheson, T E Sadler, J E Castro in British Journal of Cancer (1980)

Article

Mechanisms of C. parvum-induced coagulopathy in mice

I.v. injection of Corynebacterium parvum (CP) into C57BL and BALB/c mice caused profound coagulation changes, featuring thrombocytopenia, decreased fibrinogen, increased fibrin/fibrinogen degradation products,...

H D Mitcheson, P Hilgard, A McCraw, J E Castro in British Journal of Cancer (1980)

Article

Effects of amputation and Corynebacterium parvum on tumour metastases in mice

The effects of operation (lower-limb amputation) on the growth of the Lewis lung tumour and its metastases were studied. The role of C. parvum in counteracting these effects was investigated. Anaesthesia alone or...

J G Mosley, T E Sadler, J E Castro in British Journal of Cancer (1978)

Article

Hormonal environment of immunosuppressed mice

G Williams, R Ghanadian, A S Papadopoulos, J E Castro in British Journal of Cancer (1978)

Article

Effect of Corynebacterium parvum on peripheral blood platelets

The level of peripheral blood platelets was determined after i.v. injection of Corynebacterium parvum in normal C57BL mice and in those bearing the Lewis lung carcinoma. Twenty minutes after injection of a for...

P D Jones, T E Sadler, J E Castro in British Journal of Cancer (1977)

Article

Intravascular coagulation resulting from intravenous injection of C. parvum in mice

In mice, i.v. C. parvum induces intravascular coagulation. This is a prolonged reaction lasting up to 7 days. It results in thrombosis in hepatic vessels with consequent hepatic necrosis, and thrombosis in pulmon...

I A Lampert, P D Jones, T E Sadler, J E Castro in British Journal of Cancer (1977)

Article

Immunological mechanisms in metastatic spread and the antimetastatic effects of C. parvum

The effects of the host's immune response on metastatic spread was investigated by observing the numbers of pulmonary metastases that developed from an s.c. implant of the Lewis lung carcinoma in C57BL mice in...

P D Jones, J E Castro in British Journal of Cancer (1977)

Article

Effects of C. parvum on growth and induction of intracerebral tumours in mice

An investigation was made into the effect of Corynebacterium parvum therapy on cerebral tumours in mice. I.v. C. parvum caused a slight but significant increase in the survival of BALB/c mice injected intracerebr...

D E Osborn, T E Sadler, J E Castro in British Journal of Cancer (1977)

Article

Radiolabelling of Corynebacterium parvum and its distribution in mice

Corynebacterium parvum was labelled by growing live bacteria in the presence of [3H]thymidine. The bacteria were killed by formalin, washed thoroughly and resuspended at a concentration of 7 mg dry weight/ml. ...

T E Sadler, W A Cramp, J E Castro in British Journal of Cancer (1977)

Article

Abrogation of the anti-metastatic activity of C. parvum by antilymphocyte serum

T E Sadler, J E Castro in British Journal of Cancer (1976)

Article

Lack of immunological and anti-tumour effects of orally administered Corynebacterium parvum in mice

T E Sadler, J E Castro in British Journal of Cancer (1975)

Article

Treatment of a metastasizing murine tumour with Corynebacterium parvum

T E Sadler, J E Castro in British Journal of Cancer (1975)