13 Result(s)
within
Itai Sharon
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessBioinformatics of cyanophycin metabolism genes and characterization of promiscuous isoaspartyl dipeptidases that catalyze the final step of cyanophycin degradation
Cyanophycin is a bacterial biopolymer used for storage of fixed nitrogen. It is composed of a backbone of L-aspartate residues with L-arginines attached to each of their side chains. Cyanophycin is produced by...
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Article
Open AccessA cryptic third active site in cyanophycin synthetase creates primers for polymerization
Cyanophycin is a nitrogen reserve biopolymer in many bacteria that has promising industrial applications. Made by cyanophycin synthetase 1 (CphA1), it has a poly-L-Asp backbone with L-Arg residues attached to ...
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Article
Open AccessStructures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module
Nonribosomal peptide synthetases (NRPSs) are large modular enzymes that synthesize secondary metabolites and natural product therapeutics. Most NRPS biosynthetic pathways include an NRPS and additional protein...
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Open AccessThe chaperone HSPB1 prepares protein aggregates for resolubilization by HSP70
In human cells under stress conditions, misfolded polypeptides can form potentially cytotoxic insoluble aggregates. To eliminate aggregates, the HSP70 chaperone machinery extracts and resolubilizes polypeptide...
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Article
Open AccessNeonatal antibiotic exposure impairs child growth during the first six years of life by perturbing intestinal microbial colonization
Exposure to antibiotics in the first days of life is thought to affect various physiological aspects of neonatal development. Here, we investigate the long-term impact of antibiotic treatment in the neonatal p...
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Open AccessAuthor Correction: Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria
The original version of this Article contained errors in Fig. 4. In panel a, the labels ‘F420-reducing NiFe hydrogenase (group 3a)’ and ‘Group 2 NiFe hydrogenase’ were misplaced. These errors have been correct...
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Open AccessHydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria
The evolution of aerobic respiration was likely linked to the origins of oxygenic Cyanobacteria. Close phylogenetic neighbors to Cyanobacteria, such as Margulisbacteria (RBX-1 and ZB3), Saganbacteria (WOR-1), ...
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Article
A distinct abundant group of microbial rhodopsins discovered using functional metagenomics
Many organisms capture or sense sunlight using rhodopsin pigments1,2, which are integral membrane proteins that bind retinal chromophores. Rhodopsins comprise two distinct protein families 1 ...
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Open AccessThousands of microbial genomes shed light on interconnected biogeochemical processes in an aquifer system
The subterranean world hosts up to one-fifth of all biomass, including microbial communities that drive transformations central to Earth’s biogeochemical cycles. However, little is known about how complex micr...
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Open AccessMajor bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems
Current understanding of microorganism–virus interactions, which shape the evolution and functioning of Earth’s ecosystems, is based primarily on cultivated organisms. Here we investigate thousands of viral an...
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Unusual biology across a group comprising more than 15% of domain Bacteria
More than 15% of the bacterial domain consists of a radiation of phyla about which very little is known; here, metagenomics is used to reconstruct 8 complete and 789 draft genomes from more than 35 of these ph...
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Article
Genomic island variability facilitates Prochlorococcus–virus coexistence
Prochlorococcus cyanobacteria are extremely abundant in the oceans, as are the viruses that infect them. How hosts and viruses coexist in nature remains unclear, although the presence of both susceptible and resi...
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Article
Photosystem I gene cassettes are present in marine virus genomes
Like plant chloroplasts, the photosynthetic membranes of marine cyanobacteria contain two photosystems: photosystem II (PSII) mediates electron transfer from water to plastoquinones and PSI mediates electron t...
