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  1. No Access

    Article

    Emerging roles of GluN3-containing NMDA receptors in the CNS

  2. GluN3 subunits (A and B) were the last members of the glutamate receptor subunit family to be cloned. They assemble with GluN1 and GluN2 (A–D) subunits to form...

    3. Isabel Pérez-Otaño, Rylan S. Larsen, John F. Wesseling in Nature Reviews Neuroscience (2016)

  3. No Access

    Article

    Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models

    Huntington's disease is a neurodegenerative disorder associated with glutamate receptor dysfunction. Now Isabel Pérez-Otaño and colleagues report that the HTT protein that aggregates in the brains of individua...

    Sonia Marco, Albert Giralt, Milos M Petrovic, Mahmoud A Pouladi… in Nature Medicine (2013)

  4. No Access

    Article

    NR3A-containing NMDARs promote neurotransmitter release and spike timing–dependent plasticity

    Larsen et al. find that presynaptic NMDA receptors at neocortical synapses are heteromeric receptors containing the developmentally expressed NR3A subunit. Their data also indicate that NR3A-containing presynapti...

    Rylan S Larsen, Rebekah J Corlew, Maile A Henson, Adam C Roberts… in Nature Neuroscience (2011)

  5. No Access

    Article

    Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1

    A key step in glutamatergic synapse maturation is the replacement of developmentally expressed N-methyl-D-aspartate receptors (NMDARs) with mature forms that differ in subunit composition, electrophysiological pr...

    Isabel Pérez-Otaño, Rafael Luján, Steven J Tavalin, Markus Plomann… in Nature Neuroscience (2006)