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Article
Open AccessSparse force-bearing bridges between neighboring synaptic vesicles
Most vesicles in the interior of synaptic terminals are clustered in clouds close to active zone regions of the plasma membrane where exocytosis occurs. Electron-dense structures, termed bridges, have been rep...
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Article
Emerging roles of GluN3-containing NMDA receptors in the CNS
GluN3 subunits (A and B) were the last members of the glutamate receptor subunit family to be cloned. They assemble with GluN1 and GluN2 (A–D) subunits to form...
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Article
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models
Huntington's disease is a neurodegenerative disorder associated with glutamate receptor dysfunction. Now Isabel Pérez-Otaño and colleagues report that the HTT protein that aggregates in the brains of individua...
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Article
NR3A-containing NMDARs promote neurotransmitter release and spike timing–dependent plasticity
Larsen et al. find that presynaptic NMDA receptors at neocortical synapses are heteromeric receptors containing the developmentally expressed NR3A subunit. Their data also indicate that NR3A-containing presynapti...
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Article
Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1
A key step in glutamatergic synapse maturation is the replacement of developmentally expressed N-methyl-D-aspartate receptors (NMDARs) with mature forms that differ in subunit composition, electrophysiological pr...