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Article
Open AccessDiscovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium
Here, we describe the characteristics of the Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) epidemiological cohorts at baseline and follow-up examinations (18, 36 an...
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Article
Open AccessThe role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study
It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed twin-cycle hypo...
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Article
Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study
Unfortunately, ‘Present address’ was omitted from one of the addresses provided for Mark I. McCarthy (#26).
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Article
Open AccessGenetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a...
