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  1. Article

    Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

    As obesity progresses, adipose tissue exhibits a hypoxic and inflammatory phenotype characterised by the infiltration of adipose tissue macrophages (ATMs). In this study, we examined how adipose tissue hypoxia...

    S. Fujisaka, I. Usui, M. Ikutani, A. Aminuddin, A. Takikawa, K. Tsuneyama… in Diabetologia (2013)

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  2. Article

    Deletion of platelet-derived growth factor receptor-β improves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase IIα (Thr286Asp) transgenic mice

    The activation of platelet-derived growth factor receptor-β (PDGFR-β) signalling is increased in the glomeruli and tubules of diabetic animals. In this study, we examined the role of PDGFR-β signalling during ...

    H. Suzuki, I. Usui, I. Kato, T. Oya, Y. Kanatani, Y. Yamazaki, S. Fujisaka… in Diabetologia (2011)

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  3. Article

    Fatty acid induced insulin resistance in rat-1 fibroblasts overexpressing human insulin receptors: impaired insulin-stimulated mitogen-activated protein kinase activity

    Saturated fatty acids cause insulin resistance but the underlying molecular mechanism is still unknown. We examined the effect of saturated non-esterified fatty acids on insulin binding and action in transfec...

    I. Usui, Y. Takata, T. Imamura, H. Morioka, T. Sasaoka, T. Sawa… in Diabetologia (1997)

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