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Article
A Method to Extract Image Features and Lineaments Based on a Multi-hillshade Continuous Wavelet Transform
This paper presents a new method for extracting the image features and lineaments related to local extrema of an image or a digital elevation model (DEM) such as ridges and valleys based on the continuous wave...
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Article
Investigation of the operating conditions for a full-scale plant for hydrogen production from biomass
In this study, we analyzed the system configuration and operating conditions for a full-scale plant for hydrogen (H2) production from biomass. We considered pretreatment and upgrade processes for generating pure ...
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Article
Efficient production of 1,3-propanediol from glycerol by a newly isolated soil bacterium using fed-batch fermentation
A total of 817 Lactobacillus-like isolates were obtained from different sources, including soil, ruminant gastric juice, and fermented foods. They were screened to select the best isolate for the production of 1,...
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Article
Open AccessPrediction of metabolites associated with somatic mutations in cancers by using genome-scale metabolic models and mutation data
Oncometabolites, often generated as a result of a gene mutation, show pro-oncogenic function when abnormally accumulated in cancer cells. Identification of such mutation-associated metabolites will facilitate ...
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Article
Open AccessDurvalumab plus pazopanib combination in patients with advanced soft tissue sarcomas: a phase II trial
We aimed to determine the activity of the anti-VEGF receptor tyrosine-kinase inhibitor, pazopanib, combined with the anti-PD-L1 inhibitor, durvalumab, in metastatic and/or recurrent soft tissue sarcoma (STS). ...
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Article
Open AccessMetabolic engineering of Caldicellulosiruptor bescii for hydrogen production
Hydrogen is an alternative fuel for transportation vehicles because it is clean, sustainable, and highly flammable. However, the production of hydrogen from lignocellulosic biomass by microorganisms presents c...
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Article
Second-line chemoimmunotherapy with nivolumab and paclitaxel in immune-related biomarker-enriched advanced gastric cancer: a multicenter phase Ib/II study
We conducted a trial to evaluate the efficacy and safety of nivolumab and paclitaxel as second-line therapy for immune-related biomarker-enriched advanced gastric cancer (AGC).
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Article
Open AccessRetinal vascular occlusion risks during the COVID-19 pandemic and after SARS-CoV-2 infection
The coronavirus disease 2019 (COVID-19) has been reported to affect vascular networks including the eye. However, evidence on the causal relationship between COVID-19 infection and retinal vascular occlusions ...
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Article
Correction: Expanded spectrum of focal scleral nodule: focal scleral nodules can be bifocal
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Article
Expanded spectrum of focal scleral nodule: focal scleral nodules can be bifocal
To assess multimodal imaging findings of focal scleral nodule (FSN) to evaluate its origin and natural course.
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Article
Open AccessAnalysis of clinical and genomic profiles of therapy-related myeloid neoplasm in Korea
Therapy-related myeloid neoplasm (T-MN) rarely occurs among cancer survivors, and was characterized by poor prognosis. T-MN has germline predisposition in a considerable proportion. Here, clinical characterist...
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Article
Open AccessA single arm phase Ib/II trial of first-line pembrolizumab, trastuzumab and chemotherapy for advanced HER2-positive gastric cancer
In this multi-center phase II trial, we evaluated the efficacy and safety of a quadruplet regimen (pembrolizumab, trastuzumab, and doublet chemotherapy) as first-line therapy for unresectable or metastatic hum...
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Article
Open AccessFirst-in-human study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors
Preclinical models suggest anticancer activity of IM156, a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS). This first-in-human dose-escalation study enrolled pa...
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Article
Open AccessIncidence and risk factors of progressive nasal inner nuclear layer thickening after surgical peeling of epiretinal membrane
To assess incidence and risk factors of postoperative progressive nasal inner nuclear layer (INL) thickening after epiretinal membrane (ERM) surgery. Progressive nasal INL thickening was defined as 1.5-fold in...
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Article
Open AccessDevelopment and validation of a prognostic and predictive 32-gene signature for gastric cancer
Genomic profiling can provide prognostic and predictive information to guide clinical care. Biomarkers that reliably predict patient response to chemotherapy and immune checkpoint inhibition in gastric cancer ...
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Article
Spectral Analysis based on Wavelet Transform Maxima: Identification of Multi-order Stratigraphic Boundaries and Cycles
In sedimentology, stratigraphic sequences and cycles are ordered by time spans and physical scales, such as thickness, and bounded by discontinuities, including unconformities or flooding surfaces. Spectral an...
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Article
Open AccessEvolution and expansion of Li concentration gradient during charge–discharge cycling
To improve the performance of Li-ion batteries (LIBs), it is essential to understand the behaviour of Li ions during charge–discharge cycling. However, the analytical techniques for observing the Li ions are l...
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Article
Synergistic effect of copper and amino acid mixtures on the production of extracellular matrix proteins in skin fibroblasts
The stimulation of extracellular matrix (ECM) protein production is an interesting target to maintain normal skin structure and delay skin aging. Copper has been shown to stimulate ECM protein synthesis by act...
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Article
Open AccessPD-L1 tumour expression is predictive of pazopanib response in soft tissue sarcoma
Pazopanib, a multitargeted tyrosine kinase inhibitor, is recommended as the standard treatment for refractory soft tissue sarcoma (STS). However, there are comparatively few molecular determinants for predicti...
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Article
Progression patterns of normal-tension glaucoma groups classified by hierarchical cluster analysis
To investigate differences in progression patterns of normal-tension glaucoma (NTG) patients in three clusters classified by hierarchical cluster analysis (HCA).
