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  1. Article

    Open Access

    Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α

    Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In...

    Hoe-Yune Jung, Dongyeop Lee, Hye Guk Ryu, Bo-Hwa Choi, Younghoon Go in Scientific Reports (2017)

  2. Article

    Open Access

    Heterogeneous nuclear ribonucleoprotein A1 regulates rhythmic synthesis of mouse Nfil3 protein via IRES-mediated translation

    Nuclear factor, interleukin 3, regulated (Nfil3, also known as E4 Promoter-Binding Protein 4 (E4BP4)) protein is a transcription factor that binds to DNA and generally represses target gene expression. In the ...

    Hyo-** Kim, Hwa-Rim Lee, Ji-Young Seo, Hye Guk Ryu, Kyung-Ha Lee in Scientific Reports (2017)

  3. Article

    Open Access

    Glycogen synthase kinase 3β suppresses polyglutamine aggregation by inhibiting Vaccinia-related kinase 2 activity

    Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal expansion of polyglutamine repeats in the N-terminal of huntingtin. The amount of aggregate-prone protein is controlled by variou...

    Eunju Lee, Hye Guk Ryu, Sangjune Kim, Dohyun Lee, Young-Hun Jeong in Scientific Reports (2016)

  4. Article

    Open Access

    Correction: Corrigendum: Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells

    Many mitotic kinases have been targeted for the development of anti-cancer drugs, and inhibitors of these kinases have been expected to perform well for cancer therapy. Efforts focused on selecting good target...

    Seong-Hoon Kim, Hye Guk Ryu, Juhyun Lee, Joon Shin in Scientific Reports (2015)

  5. Article

    Open Access

    Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells

    Many mitotic kinases have been targeted for the development of anti-cancer drugs and inhibitors of these kinases have been expected to perform well for cancer therapy. Efforts focused on selecting good targets...

    Seong-Hoon Kim, Hye Guk Ryu, Juhyun Lee, Joon Shin in Scientific Reports (2015)