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Article
Open AccessA potent risk model for predicting new-onset acute coronary syndrome in patients with type 2 diabetes mellitus in Northwest China
Type 2 diabetes mellitus (T2DM) is now very prevalent in China. Due to the lower rate of controlled diabetes in China compared to that in developed countries, there is a higher incidence of serious cardiovascu...
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Article
Open AccessA potent weighted risk model for evaluating the occurrence and severity of diabetic foot ulcers
Diabetic foot ulcer (DFU) is a serious chronic complication of diabetes. This study aimed to establish weighted risk models for determining DFU occurrence and severity in diabetic patients.
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Article
PAM variants were associated with type 2 diabetes mellitus risk in the Chinese population
This study aimed to assess the association between PAM single-nucleotide polymorphisms (SNPs) and T2DM risk in the Chinese population. We performed the genotype of PAM SNPs using Agena MassARRAY in 1002 subjects....
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Article
Open AccessEstablishment of a potent weighted risk model for determining the progression of diabetic kidney disease
Diabetic kidney disease (DKD) is a severe complication of diabetes. Currently, no effective measures are available to reduce the risk of DKD progression. This study aimed to establish a weighted risk model to ...
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Article
Open AccessTauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys
Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s...
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Article
Open AccessA nonhuman primate model with Alzheimer’s disease-like pathology induced by hippocampal overexpression of human tau
Alzheimer’s disease (AD) is one of the most burdening diseases of the century with no disease-modifying treatment at this time. Nonhuman primates (NHPs) share genetic, anatomical, and physiological similaritie...
