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Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression

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  1. Article

    Open Access

    USF2-mediated upregulation of TXNRD1 contributes to hepatocellular carcinoma progression by activating Akt/mTOR signaling

    Thioredoxin reductase 1 (TXNRD1) is one of the major redox regulators in mammalian cells, which has been reported to be involved in tumorigenesis. However, its roles and regulatory mechanism underlying the pro...

    Wen-ya Huang, Zhi-bin Liao, Jia-cheng Zhang, **n Zhang… in Cell Death & Disease (2022)

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  2. Article

    Open Access

    TGF-β1 accelerates the hepatitis B virus X-induced malignant transformation of hepatic progenitor cells by upregulating miR-199a-3p

    Increasing evidence has suggested that liver cancer arises partially from transformed hepatic progenitor cells (HPCs). However, the detailed mechanisms underlying HPC transformation are poorly understood. In t...

    Ke-shuai Dong, Yan Chen, Guang Yang, Zhi-bin Liao, Hong-wei Zhang… in Oncogene (2020)

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  3. Article

    Open Access

    Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signaling in hepatocellular carcinoma

    Familiar clustering of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) has been frequently reported. However, limited information is available about the underlying molecular mechanisms in HBV-re...

    Shao-jun Zhou, Yue-ling Deng, Hui-fang Liang… in Cell Death & Differentiation (2017)

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  4. Article

    Open Access

    Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells

    Activin A, an important member of transforming growth factor-β superfamily, is reported to inhibit proliferation of mature hepatocyte. However, the effect of activin A on growth of hepatic progenitor cells is ...

    Lin Chen, Wei Zhang, Hui-fang Liang, Qiao-dan Zhou… in Cell Communication and Signaling (2014)

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