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Article
MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1
Senescence, an intricate and inevitable biological process, characterized by the gradual loss of homeostasis and declining organ functions. The pathological features of cellular senescence, including cell cycl...
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Article
Open AccessComparison of neurally adjusted ventilatory assist and synchronized intermittent mandatory ventilation in preterm infants after patent ductus arteriosus ligation: a retrospective study
This study aimed to compare the efficacy of neurally adjusted ventilatory assist (NAVA) to synchronized intermittent mandatory ventilation (SIMV) in preterm infants requiring mechanical ventilation after paten...
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Article
Finite element modeling and analysis of effect of preexisting cervical degenerative disease on the spinal cord during flexion and extension
Recent studies have emphasized the importance of dynamic activity in the development of myelopathy. However, current knowledge of how degenerative factors affect the spinal cord during motion is still limited....
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Article
Weyl Type Theorem for Bounded Linear Operator and Its Functional Calculus
Let \(\cal{H}\) H be a complex infi...
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Article
Clinical and Immunological Significance of ANKRD52 in Pan-Cancer
Ankyrin repeat domain 52 (ANKRD52) is a regulatory component of the protein phosphatase 6 (PP6) holoenzyme. Evidence has emerged to suggest involvement of ANKRD52 in tumor metastases and cancer cell escape fro...
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Chapter and Conference Paper
HHT-Singular Value and IPSO-SVM in Fault Diagnosis of Rolling
For the problem that the characterization of the gear fault signal feature is difficult to extract and the structure parameters selection of support vector machine (SVM) are based on experience leads the poor ...
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Article
Open AccessALK fusions in the pan-cancer setting: another tumor-agnostic target?
Anaplastic lymphoma kinase (ALK) alterations (activating mutations, amplifications, and fusions/rearrangements) occur in ~3.3% of cancers. ALK fusions/rearrangements are discerned in >50% of inflammatory myofibro...
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Article
Mainstreaming germline genetic testing for patients with pancreatic cancer increases uptake
Germline genetic testing is recommended for all patients with pancreatic cancer (PC) but uptake rates are low. We implemented a mainstreaming program in oncology clinics to increase testing for PC patients. Ge...
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Article
Effect of degenerative factors on cervical spinal cord during flexion and extension: a dynamic finite element analysis
Spinal cord injury (SCI) is a global problem that brings a heavy burden to both patients and society. Recent investigations indicated degenerative disease is taking an increasing part in SCI with the growth of...
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Article
Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of depression
Kaixinsan powder (KXS), a classic prescription of traditional Chinese Medicine (TCM), is widely used in the treatment of depression, but its mechanism remains unclear. The network pharmacology method was used to ...
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Article
Multi-twinned gold nanoparticles with tensile surface steps for efficient electrocatalytic CO2 reduction
CO2 reduction reactions (CO2RR) powered by renewable electricity can directly convert CO2 to hydrocarbons and fix the intermittent sustainable energy in portable chemical fuels. It is of great importance to devel...
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Article
Genome-wide identification and expression analysis of JmjC domain–containing genes in grape under MTA treatment
Histone demethylases containing the JmjC domain play an extremely important role in maintaining the homeostasis of histone methylation and are closely related to plant growth and development. Currently, the Jm...
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Article
Chemical Constituents of Buxus sinica var. parvifolia
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Article
Open AccessThe biomechanical effect of preexisting different types of disc herniation in cervical hyperextension injury
Preexisting severe cervical spinal cord compression is a significant risk factor in cervical hyperextension injury, and the neurological function may deteriorate after a slight force to the forehead. There are...
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Article
Open AccessCorrection to: Silencing long non-coding RNA CASC9 inhibits colorectal cancer cell proliferation by acting as a competing endogenous RNA of miR-576-5p to regulate AKT3
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Article
Open AccessFibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance
Fibroblast growth factor receptors (FGFRs) are aberrantly activated through single-nucleotide variants, gene fusions and copy number amplifications in 5–10% of all human cancers, although this frequency increa...
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Article
Chemical Constituents of Parasenecio quinquelobus
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Article
Chemical Constituents of Litsea lancilimba
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Article
Open AccessSilencing long non-coding RNA CASC9 inhibits colorectal cancer cell proliferation by acting as a competing endogenous RNA of miR-576-5p to regulate AKT3
Increasing studies have shown that long non-coding RNAs (lncRNAs) are regarded as important regulators in the occurrence and development of colorectal cancer (CRC). Although lncRNA CASC9 has been studied in CR...
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Protocol
Detection of Microsatellite Instability Biomarkers via Next-Generation Sequencing
A high level of microsatellite instability (MSI-H+) is an emerging predictive and prognostic biomarker for immunotherapy response in cancer. Recently, MSI-H+ has been detected in a variety of cancer types, in ...
