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Article
Open AccessDevelopment and validation of an interpretable model integrating multimodal information for improving ovarian cancer diagnosis
Ovarian cancer, a group of heterogeneous diseases, presents with extensive characteristics with the highest mortality among gynecological malignancies. Accurate and early diagnosis of ovarian cancer is of grea...
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Article
Computationally efficient gear shift strategy for hybrid electric vehicles
A collaborative control strategy for gear optimization and energy management of hybrid electric vehicles based on Pontryagin’s minimum principle (PMP) and numerical iteration is proposed in this paper. First, ...
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Article
Open AccessGenome-wide association study of kernel colour traits and mining of elite alleles from the major loci in maize
Maize kernel colour is an important index for evaluating maize quality and value and mainly entails two natural pigments, carotenoids and anthocyanins. To analyse the genetic mechanism of maize kernel colour a...
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Article
Open AccessMultigroup analysis of compositions of microbiomes with covariate adjustments and repeated measures
Microbiome differential abundance analysis methods for two groups are well-established in the literature. However, many microbiome studies involve more than two groups, sometimes even ordered groups such as st...
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Article
Open AccessGenetic dissection of maize (Zea maysL.) trace element traits using genome-wide association studies
Maize (Zea mays L.) is an important food and feed crop worldwide and serves as a a vital source of biological trace elements, which are important breeding targets. In this study, 170 maize materials were used to ...
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Article
Open AccessELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial Injury by Regulating AMPK/NLRP3 Pathway
ELABELA (ELA), a recently discovered peptide, is highly expressed in adult kidneys and the endothelium system. It has been identified as a novel endogenous ligand for the apelin receptor (APJ). This study aims...
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Article
Open AccessOral bacterial composition associated with lung function and lung inflammation in a community-based Norwegian population
The oral cavity is the gateway to the bacteria community in the lung. Disruption of the symbiotic balance of the oral microbiota has been associated with respiratory diseases. However, little is known about th...
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Article
Open AccessEndothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex
Reduction of histone deacetylase (HDAC) 2 expression and activity may contribute to amplified inflammation in patients with severe asthma. Connective tissue growth factor (CTGF) is a key mediator of airway fib...
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Article
Open AccessIDO-1 inhibitor INCB24360 elicits distant metastasis of basal extruded cancer cells in pancreatic ductal adenocarcinoma
Neoplastic cells of non-immunogenic pancreatic ductal adenocarcinoma (PDAC) express indoleamine 2,3-dioxygenase 1 (IDO-1), an immunosuppressive enzyme. The metabolites of IDO-1 in cancers provide one-carbon un...
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Article
Open AccessAssociation between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort
Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule. The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which ...
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Article
Open AccessGenome-wide identification and expression analysis of the cyclic nucleotide-gated ion channel (CNGC) gene family in Saccharum spontaneum
Cyclic nucleotide-gated ion channels (CNGCs) are nonselective cation channels that are ubiquitous in eukaryotic organisms. As Ca2+ channels, some CNGCs have also proven to be K+-permeable and involved in plant de...
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Article
Crystal of Affine \({\widehat {\mathfrak{s}\mathfrak{l}}_\ell}\) and Modular Branching Rules for Hecke Algebras of Type Dn
Let ℋq(Bn) and ℋq(Dn) denote the Hecke algebras of types Bn and Dn respectively, where q ≠ 1 is the Hecke parameter with quantum characteristic e. We prove that if Dλ is a simple ℋq(B2n)-module which splits as ...
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Chapter and Conference Paper
The Implication of Project-Based Learning with CDIO, and Team Teaching on Business-Management Course
University education nowadays emphasizes innovations in teaching and also look forward to reducing the gap between learning and using. Therefore, many innovative teaching methods have emerged. This research ad...
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Chapter
Multiple Imputation for Compositional Data (MICoDa) Adjusting for Covariates
In many applications, researchers are interested in multivariate outcomes that are compositional. However, for various reasons, including the method of collection of data, sometimes not all variables are measu...
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Article
Open AccessLinear and nonlinear correlation estimators unveil undescribed taxa interactions in microbiome data
It is well-known that human gut microbiota form an ecosystem where microbes interact with each other. Due to complex underlying interactions, some microbes may correlate nonlinearly. There are no measures in t...
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Article
Silica-confined composite form-stable phase change materials: a review
Solid–liquid phase change materials (PCMs) are a kind of important heat energy storage materials that can store/release great amounts of latent heat at a specific temperature or within a narrow temperature ran...
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Article
Open AccessAssociation between glucokinase regulator gene polymorphisms and serum uric acid levels in Taiwanese adolescents
The glucokinase regulator gene (GCKR) is located on chromosome 2p23. It plays a crucial role in maintaining plasma glucose homeostasis and metabolic traits. Recently, genome-wide association studies have revealed...
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Article
Open AccessAssociation of anemia and iron parameters with mortality among prevalent peritoneal dialysis patients in Taiwan: the AIM-PD study
In 1996, the National Health Insurance Administration of Taiwan applied a restrictive reimbursement criteria for erythropoiesis-stimulating agents (ESAs) use in patients with chronic kidney disease. The maxima...
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Article
Open AccessThe association between sleep quality and psychological distress among older Chinese adults: a moderated mediation model
Previous research has found a link between sleep quality and psychological distress. However, the underlying mechanisms of this connection have still not been well explored. The aim of this study was to examin...
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Chapter and Conference Paper
ORF-Net: Deep Omni-Supervised Rib Fracture Detection from Chest CT Scans
Most of the existing object detection works are based on the bounding box annotation: each object has a precise annotated box. However, for rib fractures, the bounding box annotation is very labor-intensive an...
