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  1. Article

    Open Access

    Osteopontin isoform c promotes the survival of cisplatin-treated NSCLC cells involving NFATc2-mediated suppression on calcium-induced ROS levels

    Tumor microenvironment (TME) critically contributed to the malignant progression of transformed cells and the chemical responses to chemotherapy reagents. Osteopontin (OPN) is a secretory onco-protein with sev...

    **g Huang, Mu Hu, Huan Niu, **g Wang, Yang Si, Shan Cheng, Wei Ding in BMC Cancer (2021)

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  2. Article

    Open Access

    Epigenetic regulation of osteopontin splicing isoform c defines its role as a microenvironmental factor to promote the survival of colon cancer cells from 5-FU treatment

    Drug resistance to 5-fluorouracil (5-FU) and recurrence after chemotherapy in colorectal cancer remain a challenge to be resolved for the improvement of patient outcomes. It is recognized that a variety of sec...

    Siyuan Chang, **g Huang, Huan Niu, **g Wang, Yang Si… in Cancer Cell International (2020)

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