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Article
Open AccessMetabolic reprograming mediated by tumor cell-intrinsic type I IFN signaling is required for CD47-SIRPα blockade efficacy
Type I interferons have been well recognized for their roles in various types of immune cells during tumor immunotherapy. However, their direct effects on tumor cells are less understood. Oxidative phosphoryla...
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Article
Machine learning-enhanced evaluation of food security across 169 economies
The assessment of global food security is imperative for sustainable development worldwide. However, limited data availability has impeded a comprehensive evaluation on a global scale. This study addresses thi...
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Article
Mesenchymal Stem Cell-Loaded Hydrogel Improves Surgical Treatment for Chronic Cerebral Ischemia
Chronic cerebral ischemia (CCI) results in a prolonged insufficient blood supply to the brain tissue, leading to impaired neuronal function and subsequent impairment of cognitive and motor abilities. Our previ...
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Article
Liquiritin inhibits TGF-β1-induced epithelial mesenchymal transition and extracellular matrix deposition in human renal proximal tubular epithelial cells by suppressing the MAPK signaling
Excessive extracellular matrix (ECM) deposition leads to renal fibrosis, a typical hallmark of chronic kidney disease. Liquiritin is a flavonoid extracted from the rhizome part of Glycyrrhiza glabra and has an...
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Article
Electrochemical Behavior of Laser Powder Bed Fusion (L-PBF) Ti–6Al–4V Alloy: Influence of Phase and Grain Boundaries on Surface Passive Film Formation
Electrochemical dissolution behavior of laser powder bed fusion (L-PBF) Ti–6Al–4V alloy is investigated in a 3.5 wt% NaCl solution through electrochemical impedance spectroscopy (EIS), potentiostatic polarizat...
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Article
Open AccessAutumn sunlight promotes aboveground carbon loss in a temperate mixed forest
Photodegradation of plant litter plays a pivotal role in the global carbon (C) cycle. In temperate forest ecosystems, the exposure of plant litter to solar radiation can be significantly altered by changes in ...
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Article
Open AccessChromosome-level genome assembly of the cereal cyst nematode Heterodera flipjevi
As an economically important plant parasitic nematode (PPN), Heterodera filipjevi causes great damage on wheat, and now it was widely recorded in many countries. While multiple genomes of PPNs have been published...
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Article
The effects of methyl jasmonate on volatile compounds and activity of aroma-related enzymes in tobacco
Flue-cured tobacco, a member of the Solanaceae family, is widely utilized as a model organism in both fundamental and applied scientific research. This study set out to evaluate the influence of the exogenous age...
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Article
Optimal strategy for enterprises’ green technology innovation considering individual disappointment avoidance and altruistic reference based on differential game theory
The achievement of the carbon peaking and carbon neutrality goals requires the joint efforts of multiple parties such as the government, enterprises, and consumers in the green supply chain, so how to maximize...
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Article
Open AccessAnti-PD-1 cis-delivery of low-affinity IL-12 activates intratumoral CD8+T cells for systemic antitumor responses
Immune checkpoint blockade (ICB) therapies function by alleviating immunosuppression on tumor-infiltrating lymphocytes (TILs) but are often insufficient to fully reactivate these dysfunctional TILs. Although i...
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Article
Will fuel switching ever happened in China’s thermal power sector? The rule of carbon market design
To assess the effectiveness of China’s emissions trading scheme (ETS) in facilitating energy structure optimization, we constructed a fuel-switching model utilizing data from 1067 generating units under the Ch...
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Article
Insomnia disorder characterized by probabilistic metastable substates using blood-oxygenation-level-dependent (BOLD) phase signals
From a clinical point of view, how to force a transition from insomnia brain state to healthy brain state by external driven stimulation is of great interest. This needs to define brain state of insomnia disor...
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Article
Open AccessAuthor Correction: Identification of an intraocular microbiota
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Article
Large-scale Preparation of Black CeOx with Stable Oxygen Vacancies
Oxygen vacancy in ceria is a crucial regulation factor for modifying materials. The reduced oxygen vacancy will undergo rapid recombination and deactivation due to the imbalance perturbation of active oxygen s...
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Article
Open AccessRecurrent neural network for predicting absence of heterozygosity from low pass WGS with ultra-low depth
The absence of heterozygosity (AOH) is a kind of genomic change characterized by a long contiguous region of homozygous alleles in a chromosome, which may cause human genetic disorders. However, no method of l...
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Article
Age Difference in the Effect of Relationship Closeness on Interpersonal Escalating Commitment
Interpersonal escalating commitment is an individual’s continued investment in a social partner regardless of the receiver’s negative feedback. It reflects the effort that people devote into maintaining and ma...
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Article
Open AccessEffect of Osteoporosis Treatments on Osteoarthritis Progression in Postmenopausal Women: A Review of the Literature
The purpose of this literature review was to determine if medications used to treat osteoporosis are also effective for treating osteoarthritis (OA).
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Article
Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic targets for human cancers
Frizzled receptors (FZDs) are key contributors intrinsic to the Wnt signaling pathway, activation of FZDs triggering the Wnt signaling cascade is frequently observed in human tumors and intimately associated w...
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Article
Open AccessTherapeutic advantage of teriparatide in very elderly patients with proximal femoral fractures: a functional and BMD analysis
Teriparatide, a recombinant parathyroid hormone, is pivotal in osteoporosis treatment, particularly in post-surgical recovery for hip fractures. This study investigates its efficacy in functional recovery post...
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Article
Open AccessA visceral organ function-focused therapeutic strategy using a 6-hour time window for patients with acute type a aortic dissection complicated by mesenteric malperfusion
Acute type A aortic dissection (ATAAD) complicated by mesenteric malperfusion is a critical and complicated condition. The optimal treatment strategy remains controversial, debate exists as to whether aortic d...
