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  1. Article

    Open Access

    IRES-mediated Wnt2 translation in apoptotic neurons triggers astrocyte dedifferentiation

    Reactive astrogliosis usually bears some properties of neural progenitors. How injury triggers astrocyte dedifferentiation remains largely unclear. Here, we report that ischemia induces rapid up-regulation of ...

    Hong Fan, Jialei Yang, Kun Zhang, Junling **ng, Baolin Guo… in npj Regenerative Medicine (2022)

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  2. Article

    Open Access

    Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain

    Ten-eleven translocation (TET) proteins, the dioxygenase for DNA hydroxymethylation, are important players in nervous system development and diseases. However, their role in myelination and remyelination after...

    Ming Zhang, Jian Wang, Kaixiang Zhang, Guozhen Lu, Yuming Liu… in Nature Communications (2021)

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  3. No Access

    Article

    Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice

    Social deficit is a core clinical feature of autism spectrum disorder (ASD) but the underlying neural mechanisms remain largely unclear. We demonstrate that structural and functional impairments occur in gluta...

    Baolin Guo, **g Chen, Qian Chen, Keke Ren, Dayun Feng, Honghui Mao… in Nature Neuroscience (2019)