7 Result(s)

Article

APC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation

The Wnt/β-catenin pathway is critical to maintaining cell fate decisions. Recent study showed that liquid–liquid-phase separation (LLPS) of Axin organized the β-catenin destruction complex condensates in a nor...

Dan Zhang, Qi-Qi Ni, Shu-Yang Wang, Wen-Feng He… in Cellular and Molecular Life Sciences (2024)

Article

ASCL2 induces an immune excluded microenvironment by activating cancer-associated fibroblasts in microsatellite stable colorectal cancer

Proficient mismatch repair or microsatellite stable (pMMR/MSS) colorectal cancers (CRCs) are vastly outnumbered by deficient mismatch repair or microsatellite instability-high (dMMR/MSI-H) tumors and lack a re...

Dan Zhang, Qi-Qi Ni, Qiao-Yan Liang, Li-Ling He, Bo-Wen Qiu, Ling-Jie Zhang… in Oncogene (2023)

Article

IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m⁶A-dependent manner

Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is associated with tumorigenesis and progression. However, the exact molecular mechanisms of IGF2BP3 in colorectal cancer ...

Li-Jie Chen, Hui-Ye Liu, Zhi-Yuan **ao, Ting Qiu, Dan Zhang… in Cell Death & Disease (2023)

Article

Retraction Note: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway

Hong-li Jiao, Bin-shu Weng, Shan-shan Yan, Zi-mo Lin, Shu-yang Wang… in Cell Death & Disease (2022)

Article

RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway

Oxysterol-binding protein like protein 3 (OSBPL3) has been shown involving in the development of several human cancers. However, the relationship between OSBPL3 and colorectal cancer (CRC), particularly the ro...

Hong-li Jiao, Bin-shu Weng, Shan-shan Yan, Zi-mo Lin, Shu-yang Wang… in Cell Death & Disease (2020)

Article

UBN2 promotes tumor progression via the Ras/MAPK pathway and predicts poor prognosis in colorectal cancer

Ubinuclein-2 (UBN2) is a nuclear protein that interacts with many transcription factors. The molecular role and mechanism of UBN2 in the development and progression of cancers, including colorectal cancer (CRC...

Ya-li Zhao, Shen-Rong Zhong, Shi-Hong Zhang, Jia-**n Bi… in Cancer Cell International (2019)

Article

miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1

miRNAs are regarded as molecular biomarkers and therapeutic targets for colorectal cancer (CRC), a series of miRNAs have been proven to involve into CRC carcinogenesis, invasion and metastasis. Aberrant miR-42...

Wen-Ting Wei, **n-**n Nian, Shu-Yang Wang, Hong-Li Jiao… in Cancer Cell International (2017)