Annals of the New York Academy of Sciences
Volume 1011 / 2004
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Chapter
Immunogenetic Aspects of Adult Onset IDDM in Korea
Insulin-dependent diabetes mellitus (IDDM) is a clinical diabetes of severe insulin deficiency, resulting from a slowly progressing autoimmune destruction process of pancreatic beta cell. Noninsulin-dependent ...
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Article
Effect of exercise on the mitochondrial DNA content of peripheral blood in healthy women
Exercise decreases insulin resistance and increases maximal exercise capacity as estimated from maximal oxygen uptake (V˙O2max). Recent reports have demonstrated that the mitochondrial DNA (mtDNA) content of blo...
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Chapter and Conference Paper
The Virtual Enterprise: Redefining the Concept
In this paper, we critique the definitions of the virtual enterprise that have appeared in the previous literature, and propose a new definition. We define a ‘pure’ virtual enterprise as an enterprise that doe...
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Book Series
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Book
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Chapter
Overview
Identification of the mitochondrion has been a tremendous achievement of accomplished scientists who tried to understand the essence of life, life energy. We now know that the mitochondrion is the intracellula...
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Article
Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
AMP-activated protein kinase (AMPK) functions as a fuel sensor in the cell and is activated when cellular energy is depleted. Here we report that α-lipoic acid (α-LA), a cofactor of mitochondrial enzymes, decr...
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Article
Polymorphisms in the leptin receptor (LEPR)—putative association with obesity and T2DM
Leptin plays an important role in regulating adipose-tissue mass. Leptin controls energy balance and food intake through the leptin receptor in the hypothalamus of the brain, which suggests that some polymorph...
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Article
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
Masato Kasuga and colleagues and Shiro Maeda and colleagues each report the independent identification of SNPs in KCNQ1 associated with type 2 diabetes in the Japanese population. Each group replicated the associ...
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Article
Abstract Neo-Plasticity and Its Architectural Manifestation in the Luis Barragan House/Studio of 1947
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Article
Open AccessS-Adenosyl-L-methionine ameliorates TNFα-induced insulin resistance in 3T3-L1 adipocytes
An association between inflammatory processes and the pathogenesis of insulin resistance has been increasingly suggested. The IκB kinase-β (IKK-β)/ nuclear factor-κB (NF-κB) pathway is a molecular mediator of ...
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Article
Leaf and stem of Vitis amurensis and its active components protect against amyloid β protein (25–35)-induced neurotoxicity
This study investigated a methanol extract from the leaf and stem of Vitis amurensis (Vitaceae) for possible neuroprotective effects on neurotoxicity induced by amyloid β protein (Aβ) (25–35) in cultured rat cort...
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Article
Lipid Profiles and Bone Mineral Density in Pre- and Postmenopausal Women in Korea
Although it has been hypothesized that an atherogenic lipid profile might be associated with lower bone mineral density (BMD), the previous results are controversial. We investigated the association between li...
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Article
Inhibitory effects of glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ(25–35)-induced neurotoxicity in cultured rat cortical neurons
This study investigated an ethanol extract from Glycyrrhizae radix (GR), the root of Glycyrrhiza uralensis (Leguminosae), for possible neuroprotective effects on neurotoxicity induced by amyloid β protein (Aβ) (2...
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Article
Neuroprotection of Ilex latifolia and caffeoylquinic acid derivatives against excitotoxic and hypoxic damage of cultured rat cortical neurons
Ilex latifolia (Aquifoliaceae), one of the primary components of “Ku-ding-cha”, has been used in Chinese folk medicine to treat headaches and various inflammatory diseases. A previous study demon...
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Article
Open AccessIdentification of a genetic locus on chromosome 4q34-35 for type 2 diabetes with overweight
The incidence of type 2 diabetes is rising rapidly because of an increase in the incidence of being overweight and obesity. Identification of genetic determinants for complex diseases, such as type 2 diabetes,...
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Article
Metabolic syndrome and the environmental pollutants from mitochondrial perspectives
The worldwide epidemic of diabetes and metabolic syndrome in the last few decades cannot be fully accounted for only by changes in the lifestyle factors, such as sedentary lifestyle and overeating. Besides gen...
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Article
Serum aryl hydrocarbon receptor ligand activity is associated with insulin resistance and resulting type 2 diabetes
Dioxin or dioxin-like compounds are ligands of the aryl hydrocarbon receptor (AhR), which is a ligand-activated nuclear transcription factor. There are limited studies about the association of serum AhR ligand...
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Article
Neuroprotective effect of phytoceramide against transient focal ischemia-induced brain damage in rats
The present study was conducted to investigate the protective effect of phytoceramide against focal transient ischemic brain damage and the underlying mechanisms. Focal transient ischemic brain damage was prod...
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Article
Open AccessNeck Circumference and Incidence of Diabetes Mellitus over 10 Years in the Korean Genome and Epidemiology Study (KoGES)
Neck circumference, a proxy for upper-body fat, may be a unique fat depot that indicates metabolic risk beyond whole body fat. We investigated whether neck circumference is associated with development of diabe...
