58 Result(s)
-
Article
Fe3O4@SiO2-APA-Amide/Imid-CuCl2 nanocomposite as an efficient and reusable nanocatalyst for ecofriendly synthesis of 1,2,3-triazole derivatives
In this methodology, a nanomagnetic copper catalyst prepared via the immobilization of CuCl2 on the surface of Fe3O4@SiO2-APA-Amide/Imid ligand and its structure identified by several spectroscopic techniques inc...
-
Article
Preparation of pH/temperature-responsive semi-IPN hydrogels based on sodium alginate and humic acid as slow-release and water-retention fertilizers
Herein, a semi-interpenetrating network (semi-IPN) hydrogel (SH/PNA) was prepared by simple free radical polymerization using N-isopropylacrylamide and 2-acrylamide-2-methylpropanesulfonic acid as monomers, po...
-
Article
Discovering covalent inhibitors of protein–protein interactions from trillions of sulfur(VI) fluoride exchange-modified oligonucleotides
Molecules that covalently engage target proteins are widely used as activity-based probes and covalent drugs. The performance of these covalent inhibitors is, however, often compromised by the paradox of effic...
-
Article
A novel EVA-based composite via ceramization toward excellent flame retardance performance and high-temperature resistance
The development of ceramifiable polymer composites is an important means to ensure public safety and meet the emergency operation of power supply lines of public facilities in case of fire. Although there have...
-
Article
Fabrication of chitosan-based interpenetrating network hydrogel via sequential amino-maleimide click reaction and photopolymerization in water
Herein, chitosan-based interpenetrating network (IPN) hydrogel was prepared in one pot via amino-maleimide click reaction and photopolymerization. First, polyethylene glycol (PEG) was modified with maleimide p...
-
Article
Comparative cytotoxicity of 177Lu on various lung cancer cells and in vivo targeting of 177Lu-labeled cetuximab
Differences in cellular radiosensitivity and the binding affinity of radiopharmaceuticals could directly affect the radiotherapeutic effects. In this study, we investigated the radionuclide (177Lu) induced radios...
-
Article
Evaluation of [99mTc]Tc-TTHMP as a SPECT imaging agent for skeletal system
TTHMP (triethylene-tetramine-hexamethylene-phosphonic acid) shows good bone-seeking ability in previous studies. In this research, [99mTc]Tc-TTHMP was prepared with the radiochemical yield of 98% and the possibl...
-
Article
Effective lutetium/ytterbium separation for no-carrier added lutetium-177 production
In order to realize no-carrier added lutetium-177 (177Lu) production through 176Yb(n, γ) 177Yb→ 177Lu process, effective separation of 177Lu from Yb target including lanthanide resin (LNR) and high performance li...
-
Article
Protonation of Chelidamic Acid: Thermodynamic Analysis and Crystal Structure
Thermodynamics of the protonation of chelidamic acid (4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid) was studied using potentiometry and calorimetry in 0.1 mol·L− 1 NaClO4 solution at 298 K under standard press...
-
Article
Preliminary evaluation and in vitro cytotoxicity studies of [131I]I-trastuzumab in HER2 expressing ovarian cancer cells
As trastuzumab is known to target the human epidermal growth factor receptor type (HER2), the potential of [131I]I-trastuzumab as a radioimmunotherapy agent was evaluated in vitro and in vivo for HER2-overexpress...
-
Article
In vitro and in vivo evaluation of a novel anti-EGFR antibody labeled with 89Zr and 177Lu
There is an urgent need to develop more specific targeted therapies for lung cancer treatment due to the its low survival rate. EGFR is a transmembrane tyrosine kinase protein that is overexpressed in lung can...
-
Article
89Zr and 177Lu labeling of anti-DR5 monoclonal antibody for colorectal cancer targeting PET-imaging and radiotherapy
Death receptor 5 (DR5) is overexpressed in many tumors. Combination of the anti-DR5 antibody with radionuclides such as lutetium-177 (177Lu) could enhance apoptosis and decrease the possibility of drug-induced re...
-
Article
Research on the effect of bubble dynamics and turbulent kinetic energy on heat transfer in mini-channels filled with metal foam
This paper presents an investigation of the boiling heat transfer of R141b in a mini-channel with a 2.42-mm inner diameter filled with metal foam. Investigations are performed at velocity of 0.01 m s−1 and tempe...
-
Article
Preparation and cellular-interaction investigation of 177Lu/FITC labeled NGR peptides
Aminopeptidase N (CD13) as the malignant cell surface marker is overexpressed on many tumor cells including lung cancer and the neovascular cell membranes. A tripeptide structure, Asn-Gly-Arg (NGR), can specif...
-
Article
Removal of uranium by biogenetic jarosite coupled with photoinduced reduction in the presence of oxalic acid: a low-cost remediation technology
As jarosite and oxalic acid are ubiquitous in nature, we investigated a remediation technology for uranium-contaminated site by photoinduced reduction coupled with adsorption of jarosite. Jarosite exhibited ex...
-
Article
Effect of inhibitors on the thermodynamics and kinetics of spontaneous combustion of coal
In order to find a low-cost and better performance inhibitor, this study chose the widely used and effective inhibitors NH4HCO3, ammonium polyphosphate (APP) and waterborne polyacrylate (PA) and designed the TG–D...
-
Article
Complexation of 1,3-Diamino-2-hydroxypropane-N,N,N',N'-tetraacetic Acid (DHPTA) with Heavy Lanthanides (Tb3+, Ho3+, Lu3+) in Aqueous Solution
Thermodynamic equilibria of complexes of 1,3-diamino-2-hydroxypropane-N,N,N',N'-tetraacetic acid (DHPTA) with heavy lanthanides (Tb3+, Ho3+ and Lu3+) in aqueous solution have been investigated with potentiometry,...
-
Article
Synergistic effects of electron shuttle AQS and Alcaligenes faecalis on photocatalytic removal of U(VI)
Photocatalytic removal of U(VI) has attracted much attention due to its advantages such as no secondary pollution and less energy consumption. Synergistic removal of U(VI) by Alcaligenes faecalis and exogenous el...
-
Article
Synthesis, structure and optical properties of novel double penetration polypseudorotaxane compound templated by branched divalent cation template
This study is directed to branched cationic template, 1,3-bis(4-cyanopyridine) propane bromine salt (Bcpyp·2Br), which connected by metal pseudohalides to form novel double penetration polymeric compound: {(Bc...
-
Article
Comparative cell uptake study of FITC-/177Lu-labeled RM26 monomer, dimer and trimer on PC-3: improving binding affinity of gastrin releasing peptide receptor (GRPR) antagonist via bivalency/trivalency
The gastrin releasing peptide receptors (GRPRs) overexpress in various tumors, which provided the opportunity for GRPR targeted tumor radiological diagnosis and therapy. In recent reports, the GPPR antagonists...
