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  1. Article

    Open Access

    Inhibition of transmembrane TNF-α shedding by a specific antibody protects against septic shock

    Transmembrane TNF-α (tmTNF-α) and secretory TNF-α (sTNF-α) display opposite effects in septic shock. Reducing tmTNF-α shedding can offset the detrimental effects of sTNF-α and increase the beneficial effect of...

    Chenxi Li, Haiyan Gu, Mingxia Yu, Peng Yang, Meng Zhang… in Cell Death & Disease (2019)

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  2. Article

    STAT1 mediates transmembrane TNF-alpha-induced formation of death-inducing signaling complex and apoptotic signaling via TNFR1

    Tumor necrosis factor-alpha (TNF-α) exists in two forms: secretory TNF-α (sTNF-α) and transmembrane TNF-α (tmTNF-α). Although both forms of TNF-α induce tumor cell apoptosis, tmTNF-α is able to kill tumor cells t...

    Ya** Jiang, Min Yu, Xuena Hu, Lu Han, Kun Yang… in Cell Death & Differentiation (2017)

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