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Article

Inhibition of transmembrane TNF-α shedding by a specific antibody protects against septic shock

Transmembrane TNF-α (tmTNF-α) and secretory TNF-α (sTNF-α) display opposite effects in septic shock. Reducing tmTNF-α shedding can offset the detrimental effects of sTNF-α and increase the beneficial effect of...

Chenxi Li, Haiyan Gu, Mingxia Yu, Peng Yang, Meng Zhang… in Cell Death & Disease (2019)