5 Result(s)
within
Helen Won
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessReversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies
The association between loss of BRCA1/2 and a homologous recombination deficiency phenotype is lineage dependent. In BRCA-associated cancers such as breast, ovarian, pancreas and prostate, this phenotype confers ...
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Article
Open AccessEnhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS
Circulating cell-free DNA from blood plasma of cancer patients can be used to non-invasively interrogate somatic tumor alterations. Here we develop MSK-ACCESS (Memorial Sloan Kettering - Analysis of Circulatin...
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Article
Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers
The ‘Competing interests’ statement of this Article has been updated; please see the accompanying Amendment. The original Article has not been corrected online.
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Article
HER kinase inhibition in patients with HER2- and HER3-mutant cancers
Somatic mutations of ERBB2 and ERBB3 (which encode HER2 and HER3, respectively) are found in a wide range of cancers. Preclinical modelling suggests that a subset of these mutations lead to constitutive HER2 acti...
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Article
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
Inhibitors of the mTOR kinase are in clinical trials for the treatment of cancer; here, mutations in mTOR that can lead to drug resistance are investigated and the results are used to design a new class of mTO...
