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  1. Article

    Open Access

    Enhanced enzymatic production of cholesteryl 6ʹ-acylglucoside impairs lysosomal degradation for the intracellular survival of Helicobacter pylori

    During autophagy defense against invading microbes, certain lipid types are indispensable for generating specialized membrane-bound organelles. The lipid composition of autophagosomes remains obscure, as does ...

    Sasikala Muthusamy, Hau-Ming Jan, Ming-Yen Hsieh in Journal of Biomedical Science (2021)

  2. Article

    Open Access

    Membrane lipid remodeling eradicates Helicobacter pylori by manipulating the cholesteryl 6'-acylglucoside biosynthesis

    Helicobacter pylori, the main cause of various gastric diseases, infects approximately half of the human population. This pathogen is auxotrophic for cholesterol which it converts to various cholesteryl α-glucosi...

    Lih-Lih Ong, Hau-Ming Jan, Hong-Hanh Thi Le in Journal of Biomedical Science (2024)