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Article
Open AccessCereulide synthetase gene cluster from emetic Bacillus cereus: Structure and location on a mega virulence plasmid related to Bacillus anthracis toxin plasmid pXO1
Cereulide, a depsipeptide structurally related to valinomycin, is responsible for the emetic type of gastrointestinal disease caused by Bacillus cereus. Recently, it has been shown that this toxin is produced by ...
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Article
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D)1,2,3,4,5,6,7,8,9,10,11. Established associations to c...
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Article
Open AccessNon-replication of an association of CTNNBL1polymorphisms and obesity in a population of Central European ancestry
A recent genome-wide association (GWA) study of U.S. Caucasians suggested that eight single nucleotide polymorphisms (SNPs) in CTNNBL1 are associated with obesity and increased fat mass. We analysed the respectiv...
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Article
Open AccessGastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups
Gastric inhibitory polypeptide (GIP) is postulated to be involved in type 2 diabetes mellitus and obesity. It exerts its function through its receptor, GIPR. We genotyped three GIPR SNPs (rs8111428, rs2302382 and...
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Article
Open AccessMutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
The orexigenic effects of cannabinoids are limited by activation of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH). The aim of this study was to analyse whether FAAH alleles are associated...
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Article
Genome-wide association study identifies five loci associated with lung function
Martin Tobin and colleagues present genome-wide association studies for pulmonary function as part of the SpiroMeta consortium.
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Article
Open AccessLarge effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)
The polycystic ovary syndrome (PCOS), a common endocrine disorder in women of child-bearing age, mainly characterised by chronic anovulation and hyperandrogenism, is often associated with insulin resistance (I...
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Article
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly di...
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Article
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Richard Watanabe and colleagues of the MAGIC consortium report meta-analyses of genome-wide association studies to glucose levels two hours after an oral glucose challenge. They identify variants in GIPR associat...
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Article
Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Nat. Genet. 42, 105–116 (2010); published online 17 January 2010; corrected after print 26 March 2010 In the version of this article initially published, there were several errors in the author affiliations. T...
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Article
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Mark McCarthy and colleagues identify twelve new risk loci for type 2 diabetes through a large-scale genome-wide association and replication study in individuals of European ancestry. The identified loci affec...
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Article
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Ruth Loos and colleagues report results of a large genome-wide association study for body mass index. They identify 18 new loci associated with this trait, some of which map near key hypothalamic regulators of...
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Article
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Cecilia Lindgren and colleagues report results of a large-scale genome-wide association study for waist-to-hip ratio, a measure of body fat distribution. They identify 13 new loci associated with this trait, s...
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Article
Correction: Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Nat. Genet. 42, 579–589 (2010); published online 27 June 2010; corrected after print 27 August 2010 In the version of this article initially published, there was an error in Table 1. Specifically, for rs594532...
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Article
Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Nat. Genet. 42, 949–960 (2010); published online 10 October 2010; corrected after print 12 October 2011 In the version of this article initially published, there were errors in Table 1. Specifically, for eight...
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Article
Genomweite Assoziationsstudien (GWAS) — Möglichkeiten und Grenzen
GWAS have brought many successes to detect DNA-variants for common diseases and other traits. Feasibility to genotype a large amount of SNPs cost efficiently in big populations with various study designs benef...
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Article
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Jose Florez, Claudia Langenberg, Erik Ingelsson, Inga Prokopenko, Inês Barroso and colleagues perform large-scale association analyses using the Metabochip to gain further insights into the genetic architectur...
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Article
Open AccessMutation screen in the GWAS derived obesity gene SH2B1including functional analyses of detected variants
The SH2B1 gene (Src-homology 2B adaptor protein 1 gene) is a solid candidate gene for obesity. Large scale GWAS studies depicted markers in the vicinity of the gene; animal models suggest a potential relevance fo...
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Article
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Erik Ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and clinical obesit...
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Article
Systematic identification of trans eQTLs as putative drivers of known disease associations
Lude Franke and colleagues report the results of a large expression QTL study performed on peripheral blood samples from 5,311 individuals. They identify trans-eQTL effects for 103 independent loci that were prev...
