34 Result(s)
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Article
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D)1,2,3,4,5,6,7,8,9,10,11. Established associations to c...
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Genome-wide association study identifies five loci associated with lung function
Martin Tobin and colleagues present genome-wide association studies for pulmonary function as part of the SpiroMeta consortium.
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Article
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly di...
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Article
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Richard Watanabe and colleagues of the MAGIC consortium report meta-analyses of genome-wide association studies to glucose levels two hours after an oral glucose challenge. They identify variants in GIPR associat...
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Article
Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Nat. Genet. 42, 105–116 (2010); published online 17 January 2010; corrected after print 26 March 2010 In the version of this article initially published, there were several errors in the author affiliations. T...
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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Mark McCarthy and colleagues identify twelve new risk loci for type 2 diabetes through a large-scale genome-wide association and replication study in individuals of European ancestry. The identified loci affec...
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Article
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Ruth Loos and colleagues report results of a large genome-wide association study for body mass index. They identify 18 new loci associated with this trait, some of which map near key hypothalamic regulators of...
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Cecilia Lindgren and colleagues report results of a large-scale genome-wide association study for waist-to-hip ratio, a measure of body fat distribution. They identify 13 new loci associated with this trait, s...
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Article
Correction: Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Nat. Genet. 42, 579–589 (2010); published online 27 June 2010; corrected after print 27 August 2010 In the version of this article initially published, there was an error in Table 1. Specifically, for rs594532...
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Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Nat. Genet. 42, 949–960 (2010); published online 10 October 2010; corrected after print 12 October 2011 In the version of this article initially published, there were errors in Table 1. Specifically, for eight...
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Article
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Jose Florez, Claudia Langenberg, Erik Ingelsson, Inga Prokopenko, Inês Barroso and colleagues perform large-scale association analyses using the Metabochip to gain further insights into the genetic architectur...
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Article
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Erik Ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and clinical obesit...
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Article
Systematic identification of trans eQTLs as putative drivers of known disease associations
Lude Franke and colleagues report the results of a large expression QTL study performed on peripheral blood samples from 5,311 individuals. They identify trans-eQTL effects for 103 independent loci that were prev...
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Article
Common variants associated with plasma triglycerides and risk for coronary artery disease
Sekar Kathiresan and colleagues examine 185 common variants using a modified mendelian randomization approach and provide evidence supporting a causal role of triglyceride-rich lipoproteins in the development ...
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Andrew Morris, Mark McCarthy, Michael Boehnke and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes, including 26,488 cases and 83,964 controls from populations of Europe...
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Genome-wide association analysis identifies six new loci associated with forced vital capacity
Stephanie London, Martin Tobin and colleagues report meta-analyses of genome-wide association studies for forced vital capacity (FVC), a spirometric measure of pulmonary function that reflects lung volume. The...
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Article
Defining the role of common variation in the genomic and biological architecture of adult human height
Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci signif...
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Article
The impact of low-frequency and rare variants on lipid levels
Samuli Ripatti and colleagues report the results of a genome-wide association study for circulating lipid levels based on 1000 Genomes Project imputation. Their results implicate several new loci, refine the a...
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Article
Open AccessCharacterization of whole-genome autosomal differences of DNA methylation between men and women
Disease risk and incidence between males and females reveal differences, and sex is an important component of any investigation of the determinants of phenotypes or disease etiology. Further striking differenc...
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Genetic fine map** and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Kyle Gaulton, Mark McCarthy, Andrew Morris and colleagues report fine map** and genomic annotation of 39 established type 2 diabetes susceptibility loci. They find that the set of potential causal variants i...
