-
Article
Open AccessClinical analysis of 1301 children with hand and foot fractures and growth plate injuries
Fractures of hands and feet are common in children, but relevant epidemiological studies are currently lacking. We aim to study the epidemiological characteristics of hand and foot fractures and growth plate i...
-
Article
Open AccessCircHAS2 activates CCNE2 to promote cell proliferation and sensitizes the response of colorectal cancer to anlotinib
Tyrosine kinase inhibitors (TKIs) are crucial in the targeted treatment of advanced colorectal cancer (CRC). Anlotinib, a multi-target TKI, has previously been demonstrated to offer therapeutic benefits in pre...
-
Chapter and Conference Paper
Psychological Perspectives on the Influence of Robotic Emotional Cues on Human User Interaction Intention
Intelligent robots are a highly visible development in the field of science and technology, and have been undergoing a technological revolution in the last decade, driven by Industry 4.0, the Internet of Thing...
-
Chapter and Conference Paper
Interpretability Meets Generalizability: A Hybrid Machine Learning System to Identify Nonlinear Granger Causality in Global Stock Indices
Globalization has posed challenges to financial risk management, connecting markets with each other, and making it more difficult to diversify the portfolio to uncorrelated markets than ever in history. In lig...
-
Article
Open AccessThe dynamic alteration of transcriptional regulation by crucial TFs during tumorigenesis of gastric cancer
The mechanisms of Gastric cancer (GC) initiation and progression are complicated, at least partly owing to the dynamic changes of gene regulation during carcinogenesis. Thus, investigations on the changes in r...
-
Article
FOXK2 transcriptionally activating VEGFA induces apatinib resistance in anaplastic thyroid cancer through VEGFA/VEGFR1 pathway
Anaplastic thyroid carcinoma (ATC) is a rare and extremely aggressive type of thyroid cancer, and the potential mechanisms involved in ATC progression remains unclarified. In this study, we found that forkhead...
-
Article
The role of anlotinib-mediated EGFR blockade in a positive feedback loop of CXCL11-EGF-EGFR signalling in anaplastic thyroid cancer angiogenesis
Hypoxia-induced angiogenesis functions importantly in anaplastic thyroid cancer (ATC) progression. However, the therapeutic potential of broad-spectrum anti-angiogenic agent remains undefined. Anlotinib conven...
-
Article
Open AccessThe role of E26 transformation-specific variant transcription factor 5 in colorectal cancer cell proliferation and cell cycle progression
E26 transformation-specific variant transcription factor 5 (ETV5) contributes to tumor growth and progression and promotes colorectal cancer (CRC) angiogenesis. Previous studies indicate that ETV5 may regulate...
-
Article
Optimization of the O3/H2O2 process with response surface methodology for pretreatment of mother liquor of gas field wastewater
The present study reports the use of the O3/H2O2 process in the pretreatment of the mother liquor of gas field wastewater (ML-GFW), obtained from the multi-effect distillation treatment of the gas field wastewate...
-
Article
Open AccessCorrection: Targeting tumor cell-derived CCL2 as a strategy to overcome Bevacizumab resistance in ETV5+ colorectal cancer
A Correction to this paper has been published: https://doi.org/10.1038/s41419-020-03208-z
-
Article
Open AccessTargeting tumor cell-derived CCL2 as a strategy to overcome Bevacizumab resistance in ETV5+ colorectal cancer
In our previous study, ETV5 mediated-angiogenesis was demonstrated to be dependent upon the PDGF-BB/PDGFR-β/Src/STAT3/VEGFA pathway in colorectal cancer (CRC). However, the ability of ETV5 to affect the effica...
-
Article
Open AccessFGFR3△7–9 promotes tumor progression via the phosphorylation and destabilization of ten-eleven translocation-2 in human hepatocellular carcinoma
Overexpression of fibroblast growth factor receptor 3 (FGFR3) correlates with more severe clinical features of hepatocellular carcinoma (HCC). Our previous study has shown that FGFR3∆7–9, a novel splicing mutatio...
-
Article
Open AccessApatinib-induced protective autophagy and apoptosis through the AKT–mTOR pathway in anaplastic thyroid cancer
Apatinib, an inhibitor of vascular endothelial growth factor receptor-2, has been shown to promote anti-cancer action across a wide range of malignancies, including gastric, lung, and breast cancers. Our previ...
