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  1. Article

    Open Access

    Effects of Bacillus subtilis iturin A on HepG2 cells in vitro and vivo

    Iturin A with cyclic peptide and fatty acid chain isolated from Bacillus subtilis fermentation shows a variety of biological activities. Among them, the anticancer activity attracted much attention. However, the ...

    Haobin Zhao, Lu Yan, Ling Guo, Hui Sun, Qingsheng Huang, Dongyan Shao… in AMB Express (2021)

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  2. No Access

    Article

    Development of a paper-based method to detect Hg2+ in waste water using iturin from Bacillus subtilis

    Colorimetric, fluorescence, and paper-based method were developed to measure the Hg2+ level in water using iturin A, a lipopeptide produced by Bacillus subtilis. Firstly, iturin was used to synthesize highly stab...

    **xi Zhao, Chongyang Ai, Zhenzhu Li, **aoguang Xu… in Applied Microbiology and Biotechnology (2019)

  3. No Access

    Article

    Synthesis of silver nanoparticles and its contribution to the capability of Bacillus subtilis to deal with polluted waters

    Bacillus subtilis widely exists in environment and shows a capability to deal with heavy metals and dyes in polluted waters by adsorption or biological oxidation and reduction. Little is known about the roles of ...

    **xi Zhao, Lu Yan, **aoguang Xu, Haobin Zhao… in Applied Microbiology and Biotechnology (2019)

  4. No Access

    Article

    Capability of iturin from Bacillus subtilis to inhibit Candida albicans in vitro and in vivo

    Candida albicans is a fungal pathogen that is difficult to cure clinically. The current clinic C. albicans-inhibiting drugs are very harmful to humans. This study revealed the potential of iturin fractions from B...

    Shuzhen Lei, Haobin Zhao, Bing Pang, Rui Qu… in Applied Microbiology and Biotechnology (2019)

  5. No Access

    Article

    Origination, change, and modulation of geriatric disease-related gut microbiota during life

    The age-related changes in the diversity and composition of the gut microbiota are well described in recent studies. These changes have been suggested to be influenced by age-associated weakening of the immune...

    Muhammad Shahid Riaz Rajoka, Haobin Zhao, Na Li… in Applied Microbiology and Biotechnology (2018)

  6. No Access

    Article

    Production of bioproducts by endophytic fungi: chemical ecology, biotechnological applications, bottlenecks, and solutions

    Endophytes are microorganisms that colonize the interior of host plants without causing apparent disease. They have been widely studied for their ability to modulate relationships between plants and biotic/abi...

    Lu Yan, Haobin Zhao, **xi Zhao, **aoguang Xu… in Applied Microbiology and Biotechnology (2018)

  7. Article

    Open Access

    Potential of Bacillus subtilis lipopeptides in anti-cancer I: induction of apoptosis and paraptosis and inhibition of autophagy in K562 cells

    The lipopeptide iturin from Bacillus subtilis has been found to have a potential inhibitory effect on breast cancer, alveolar adenocarcinoma, renal carcinoma, and colon adenocarcinoma. In this study, the potentia...

    Haobin Zhao, Lu Yan, **aoguang Xu, Chunmei Jiang, Junling Shi, Yawen Zhang… in AMB Express (2018)

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  8. No Access

    Article

    Biological activity of lipopeptides from Bacillus

    The lipopeptides of Bacillus are small metabolites that contain a cyclic structure formed by 7–10 amino acids (including 2–4 d-amino acids) and a beta-hydroxy fatty acid with 13–19 C atoms. These lipopeptides exh...

    Haobin Zhao, Dongyan Shao, Chunmei Jiang… in Applied Microbiology and Biotechnology (2017)