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Article
Open AccessEdible exosome-like nanoparticles from portulaca oleracea L mitigate DSS-induced colitis via facilitating double-positive CD4+CD8+T cells expansion
Plant-derived exosome-like nanoparticles (PDENs) have been paid great attention in the treatment of ulcerative colitis (UC). As a proof of concept, we isolated and identified Portulaca oleracea L-derived exoso...
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Article
Open AccessStem cell-derived intestinal organoids: a novel modality for IBD
The organoids represent one of the greatest revolutions in the biomedical field in the past decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly similar to that of the tissu...
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Article
Open AccessEmerging role of bacterial outer membrane vesicle in gastrointestinal tract
Bacteria form a highly complex ecosystem in the gastrointestinal (GI) tract. In recent years, mounting evidence has shown that bacteria can release nanoscale phospholipid bilayer particles that encapsulate nuc...
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Article
Open AccessEpigenetic DNA methylation of Zbtb7b regulates the population of double-positive CD4+CD8+ T cells in ulcerative colitis
Ulcerative colitis (UC) is a heterogeneous disorder with complex pathogenesis. Therefore, in the present study, we aimed to assess genome-wide DNA methylation changes associated explicitly with the pathogenesi...
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Article
Open AccessCharacterization of short-chain fatty acids in patients with ulcerative colitis: a meta-analysis
Studies investigating the changes in short-chain fatty acids (SCFAs) in patients with ulcerative colitis (UC) have yielded inconsistent results. We performed a meta-analysis of studies that investigated the al...
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Article
Open AccessSelection strategy of dextran sulfate sodium-induced acute or chronic colitis mouse models based on gut microbial profile
Dextran sulfate sodium (DSS) replicates ulcerative colitis (UC)-like colitis in murine models. However, the microbial characteristics of DSS-triggered colitis require further clarification. To analyze the chan...
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Article
The effect of different combinations of antibiotic cocktails on mice and selection of animal models for further microbiota research
The gut microbiota is closely related to host health and disease. However, there are no suitable animal models available at present for exploring its functions. We analyzed the effect of 3 different antibiotic...
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Article
Do higher resource capture ability and utilization efficiency facilitate the successful invasion of native plants?
The great damage caused by native invasive species on natural ecosystems is prompting increasing concern worldwide. Many studies have focused on exotic invasive species. In general, exotic invasive plants have...
