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Article
Mammalian integrated stress responses in stressed organelles and their functions
The integrated stress response (ISR) triggered in response to various cellular stress enables mammalian cells to effectively cope with diverse stressful conditions while maintaining their normal functions. Fou...
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Article
Open AccessCharge-density wave mediated quasi-one-dimensional Kondo lattice in stripe-phase monolayer 1T-NbSe2
The heavy fermion physics is dictated by subtle competing exchange interactions, posing a challenge to their understanding. One-dimensional (1D) Kondo lattice model has attracted special attention in theory, b...
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Article
Open AccessElevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice
Kirsten rat sarcoma (KRAS) and mutant KRASG12D have been implicated in human cancers, but it remains unclear whether their activation requires ubiquitination. This study aimed to investigate whether and how F-box...
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Article
Head and neck MRI-based T stage and [18F]FDG PET/CT-based N/M stage improved prognostic stratification in primary nasopharyngeal carcinoma
To evaluate whether MRI-based T stage (TMRI), [18F]FDG PET/CT-based N (NPET/CT), and M stage (MPET/CT) are superior in NPC patients’ prognostic stratification based on long-term survival evidences, and whether TN...
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Article
Effects of acute heat stress on haemato-biochemical parameters, oxidative resistance ability, and immune responses of hybrid yellow catfish (pelteobagrus fulvidraco × P. vachelli) juveniles
This study investigated the effect of heat stress on the physiological parameters, oxidation resistance ability and immune responses in juvenile hybrid yellow catfish. Heat stress group exposed to 35 °C and co...
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Article
Open AccessPoricoic acid A suppresses renal fibroblast activation and interstitial fibrosis in UUO rats via upregulating Sirt3 and promoting β-catenin K49 deacetylation
Renal interstitial fibrosis is the common pathological process of various chronic kidney diseases to end-stage renal disease. Inhibition of fibroblast activation attenuates renal interstitial fibrosis. Our pre...
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Article
An Effective Platform for SARS-CoV-2 Prevention by Combining Neutralization and RNAi Technology
At present, the coronavirus disease 2019 (COVID-19) pandemic is a global health crisis. Scientists all over the globe are urgently looking forward to an effective solution to prevent the spread of the epidemic...
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Article
An Investigation into the Effect of Length Scale (Nano to Micron) of Cerium Oxide Particles on the Mechanical and Flammability Response of Magnesium
Pure magnesium (Mg) has intrinsic drawbacks such as low room temperature ductility, wet corrosion resistance, and flammability thereby restricting its widespread acceptance in industrial applications. The flam...
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Article
Open AccessAO distractor and manual traction reduction techniques repair in distal tibial fractures: a comparative study
Minimally invasive plate osteosynthesis (MIPO) via percutaneous plate placement on the distal medial tibia can be performed with minimizes soft tissue injury and produces good clinical results. However, the di...
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Article
Tracking Neural Stem Cells in vivo: Achievements and Limitations
Neural stem cell (NSC) therapies are develo** rapidly and have been proposed as a treatment option for various neurological diseases, such as stroke, Parkinson's disease and multiple sclerosis. However, moni...
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Article
Selenium Alleviates Inflammation in Staphylococcus aureus-Induced Mastitis via MerTK-Dependent Activation of the PI3K/Akt/mTOR Pathway in Mice
Mastitis caused by Staphylococcus aureus infection not only causes serious economic losses, but also affects human health. Se plays an important role in body immunity. However, the mechanisms by which Se regulate...
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Article
KCNN4-mediated Ca2+/MET/AKT axis is promising for targeted therapy of pancreatic ductal adenocarcinoma
As a member of the potassium calcium-activated channel subfamily, increasing evidence suggests that KCNN4 was associated with malignancies. However, the roles and regulatory mechanisms of KCNN4 in PDAC have be...
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Chapter and Conference Paper
Numerical Simulation of Differential Settlement Resistance for Reinforced Joint Between New and Existing Pavement with RoadMesh Steel Wire Mesh
In order to analyze the ability of longitudinal cracking resistance due to differential settlement between new and existing subgrade in the joint between new and existing pavement reinforced by RoadMesh steel ...
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Reference Work Entry In depth
Pain
Pain is one of the most common causes of suffering. The physiological function of pain is to alert the body of potentially noxious conditions encountered from the external or internal environment. Pain can be ...
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Article
Protective Effect of Tangshen Formula (糖肾方) on Interstitial Cells of Cajal in Colon of Diabetic Rats
To explore the effect of Tangshen Formula (糖肾方, TSF), a Chinese herbal medicine, on interstitial cells of Cajal (ICC) in the colon of diabetic rats.
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Article
Effects of acute hypoxia stress on hemato-biochemical parameters, oxidative resistance ability, and immune responses of hybrid yellow catfish (Pelteobagrus fulvidraco × P. vachelli) juveniles
Stress-induced by low water-dissolved oxygen (DO) negatively influences the overall fish performances. Hybrid yellow catfish (Pelteobagrus fulvidraco × P. vachelli) was subjected to 2 DO levels: 1.5 mg/L (hypoxia...
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Article
Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia
Sepsis is life-threatening organ dysfunction due to dysregulated systemic inflammatory and immune response to infection, often leading to cognitive impairments. Growing evidence shows that artemisinin, an anti...
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Article
Open AccessRIG-I, a novel DAMPs sensor for myoglobin, activates NF-κB/caspase-3 signaling in CS-AKI model
Acute kidney injury (AKI) is the main life-threatening complication of crush syndrome (CS), and myoglobin is accepted as the main pathogenic factor. The pattern recognition receptor retinoicacid-inducible gene...
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Article
Open AccessMulti-omics analysis reveals the glycolipid metabolism response mechanism in the liver of genetically improved farmed Tilapia (GIFT, Oreochromis niloticus) under hypoxia stress
Dissolved oxygen (DO) in the water is a vital abiotic factor in aquatic animal farming. A hypoxic environment affects the growth, metabolism, and immune system of fish. Glycolipid metabolism is a vital energy ...
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Chapter and Conference Paper
Experimental Study on the Relationship Between Ablation of Circuit Breaker Electrical Life and Dynamic Resistance
Dynamic resistance can reflect the ablation of arc contacts in circuit breaker at the moment of opening and closing operation, and thus indirectly reflect the condition of the circuit breaker and its subsequen...
