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    Article

    Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states

    In humans, tissue injury and depression can both cause pain hypersensitivity, but whether this involves distinct circuits remains unknown. Here, we identify two discrete glutamatergic neuronal circuits in male...

    **a Zhu, Hao-Di Tang, Wan-Ying Dong, Fang Kang, An Liu, Yu Mao in Nature Neuroscience (2021)

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    Article

    A neural circuit for the suppression of feeding under persistent pain

    In humans, persistent pain often leads to decreased appetite. However, the neural circuits underlying this behaviour remain unclear. Here, we show that a circuit arising from glutamatergic neurons in the anter...

    Hao-Di Tang, Wan-Ying Dong, Rui Hu, Ji-Ye Huang, Zhao-Huan Huang in Nature Metabolism (2022)

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    Article

    Brain regulation of gastric dysfunction induced by stress

    Psychological and physical stressors have been implicated in gastric disorders in humans. The mechanism coupling the brain to the stomach underlying stress-induced gastric dysfunction has remained elusive. Her...

    Wan-Ying Dong, **a Zhu, Hao-Di Tang, Ji-Ye Huang, Meng-Yu Zhu in Nature Metabolism (2023)

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    Article

    Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

    Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we showed that the splenic T helper 2 (TH2) immune cell response is differentially regulated in male mice with acute versus chr...

    **a Zhu, Ji-Ye Huang, Wan-Ying Dong, Hao-Di Tang, Si Xu, Qielan Wu in Nature Neuroscience (2024)