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  1. Article

    Open Access

    TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression

    Insulin regulates blood glucose levels by binding its receptor and stimulating downstream proteins through the insulin receptor substrate (IRS). Impaired insulin signalling leads to metabolic syndrome, but the...

    Jun-Ha Hwang, A Rum Kim, Kyung Min Kim, Jung Il Park, Ho Taek Oh in Nature Communications (2019)

  2. Article

    Open Access

    Enhanced CD25+Foxp3+ regulatory T cell development by amodiaquine through activation of nuclear receptor 4A

    CD4+ T cells play key roles in the regulation of immune responses against pathogenic infectious antigens via development into effector T helper and induced regulatory T (iTreg) cells. Particularly, CD4+CD25+Foxp3

    Hee Yeon Won, Ji Hyun Shin, Sera Oh, Hana Jeong, Eun Sook Hwang in Scientific Reports (2017)

  3. Article

    Open Access

    Novel benzoxazole derivatives DCPAB and HPAB attenuate Th1 cell-mediated inflammation through T-bet suppression

    Interferon-γ (IFN-γ), a critical inflammatory cytokine, is primarily produced by T helper 1 (Th1) cells and accelerates the pathogenesis of inflammatory colitis. Pharmacological suppression of IFN-γ production...

    Yeon Ji Oh, Darong Kim, Sera Oh, Eun Jung Jang, Hee Yeon Won in Scientific Reports (2017)